Unicort N Ointment
Hydrocortisone Acetate 0.5% + Neomycin Sulphate 0.5% Topical
0.5%+0.5%
G. A. Company Ltd.
| Pack size | 15 gm |
|---|---|
| Unite Price | 16.05 BDT |
Indications
Unicort N Ointment is used for:
Burns, Eczema, Infected wounds & ulcers, Pyogenic & seborrhoeic dermatitis
Adult Dose
Topical/Cutaneous
Corticosteroid-responsive dermatoses
Adult: Apply cream/ointment onto affected area 2-3 times as needed.
Child Dose
Renal Dose
Administration
Contra Indications
Viral/fungal infections, tubercular or syphilitic lesions, bacterial infections unless used in conjunction with appropriate chemotherapy.
Precautions
CHF, hypertension, DM, epilepsy, elderly, patients on prolonged therapy. Gradual withdrawal, pregnancy and lactation.
Pregnancy-Lactation
Interactions
Hydrocortisone: Thiazides may enhance hyperglycaemia and hypokalaemia caused by corticosteroids. Increased incidence of peptic ulcer or GI bleeding with concurrent NSAIDs admin. Response to anticoagulants altered. Dose of antidiabetics and antihypertensives needs to be increased. Decreases serum conc of salicylates and antimuscarinic agents. Ethanol may enhance gastric mucosal irritation. Reduced efficacy with concurrent use of carbamazepine, phenytoin, primidone, barbiturates and rifampicin. Mutual inhibition of metabolism between ciclosporin and corticosteroids increase plasma conc of both drugs. Enhanced effect in women taking oestrogens or oral contraceptives.
Neomycin: Additive nephrotoxic and neurotoxic effect w/ other aminoglycosides (e.g. paromomycin), bacitracin, cisplatin, vancomycin, amphotericin B, polymyxin B, colistin and viomycin. Enhanced toxicity w/ potent diuretics (e.g. ethacrynic acid, furosemide). May impair the absorption of other drugs (e.g. phenoxymethylpenicillin, digoxin, methotrexate and some vit). May reduce the efficacy of OCs. May enhance the effect of acarbose. May enhance the effect of non-depolarising muscle relaxants. May antagonise the parasympathomimetic effect of neostigmine and pyridostigmine. May increase the risk of hypocalcaemia in patients receiving bisphosphonates. May alter INR when given w/ anticoagulants. May inactivate oral typhoid vaccine.
Side Effects
Side effects of Hydrocortisone Acetate 0.5% + Neomycin Sulphate 0.5% Topical :
Burning, itching, irritation, hypopigmentaion, skin atrophy, striae.
Mode of Action
Hydrocortisone is a corticosteroid used for its anti-inflammatory and immunosuppressive effects. Its anti-inflammatory action is due to the suppression of migration of polymorphonuclear leukocytes and reversal of increased capillary permeability. It may also be used as replacement therapy in adrenocortical insufficiency.
Neomycin is an aminoglycoside antibiotic. It binds to 30S ribosomal subunits of bacterial ribosome thus inhibiting protein synthesis and generating errors in genetic code transcription causing cell death. It acts against many gram-negative aerobes and some gram-positive aerobes. It lacks activity against fungi, viruses and most anaerobic bacteria.
Note
Unicort N 0.5%+0.5% Ointment generic name is Hydrocortisone Acetate 0.5% + Neomycin Sulphate 0.5% Topical. Unicort N 0.5%+0.5% Ointment is manufactured by G. A. Company Ltd.Unicort N is availble in all over Bangladesh.
Mes BD drug index information on Unicort N Ointment is not intended for diagnosis, medical advice or treatment; neither intended to be a substitute for the exercise of professional judgment.