Trimacontin Tablet

Trimetazidine
35 mg
Mundipharma (Bangladesh) Pvt. Ltd.
Pack size 30's pack
Unite Price 9.00 BDT

Indications

Trimacontin Tablet is used for: Ischaemic heart disease, Angina pectoris, Coronary heart disease

Adult Dose

Oral Angina pectoris Adult: 40-60 mg daily in 2-3 divided doses. Modified-release tab: 35 mg bid.

Child Dose

Renal Dose

Renal impairment: CrCl (ml/min) Dosage Recommendation <30 Contraindicated. 30-60 20 mg bid. Modified-release: 35 mg once daily.

Administration

Should be taken with food.

Contra Indications

Hypersensitivity to Trimetazidine Dihydrochloride.

Precautions

Moderate renal impairment (CrCl 30-60 mL/min). Pregnancy. Patient Counselling May cause dizziness and drowsiness, if affected, do not drive or operate machinery. Although teratological studies have not shown any drug related adverse effects on the course and outcome of pregnancy, the use in pregnant women is not recommended. It is not known whetherTrimetazidine passes into breast milk or not. This medication should be used while breast feeding only if the potential benefits outweigh risks to the nursing infants.

Pregnancy-Lactation

Interactions

MAOIs, nifedipine. May potentiate the effects of other antianginals.

Side Effects

Side effects of Trimetazidine : Dizziness, headache, abdominal pain, dyspepsia, diarrhoea, nausea, vomiting, pruritus, rash, urticaria, asthenia. Rarely, tachycardia, palpitations, extrasystoles, orthostatic hypotension, arterial hypotension, flushing.

Mode of Action

Trimetazidine is a cellular acting anti-ischaemic agent. It has 3 main properties by which it acts as a cytoprotective agent. It inhibits the anaerobic glycolysis and fatty acid metabolism, thus allowing only aerobic glycolysis. This action helps to restore the energy balance in the cell. It inhibits acidosis and free radical accumulation in the cell. All these action help the cell to restore the normal ionic and metabolic balance.

Note

Trimacontin 35 mg Tablet generic name is Trimetazidine. Trimacontin 35 mg Tablet is manufactured by Mundipharma (Bangladesh) Pvt. Ltd.Trimacontin is availble in all over Bangladesh. Mes BD drug index information on Trimacontin Tablet is not intended for diagnosis, medical advice or treatment; neither intended to be a substitute for the exercise of professional judgment.

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