Topiclo-S Ointment

Clobetasol Propionate + Salicylic Acid topical

.05 gm + 3 gm/100 gm

Eskayef Pharmaceuticals Ltd.

Pack size	10gm,20gm tube
Unite Price	80.00,120.00 BDT

Indications

Topiclo-S Ointment is used for: Psoriasis, Burns, Acne vulgaris, Eczema, Dyskeratosis, Ichthyosis, Warts, Hyperkeratosis, Corn, Callus, Seborrhea, Scaly skin disease, Hair loss, Sweating feet, Dermatitis

Adult Dose

Adult: Topical Acne; Hyperkeratotic and scaling skin conditions As 2-6% Salicylic Acid preparation: Apply >3 times/day.

Child Dose

Renal Dose

Administration

Contra Indications

Hypersensitivity

Precautions

Not for prolonged use in high concentrations and on large areas of the body. Impaired peripheral circulation or diabetes. Avoid broken skin, mouth, eyes, mucous membranes and anogenital region.

Pregnancy-Lactation

Interactions

Clobetasol Propionate: Increased systemic exposure w/ CYP3A4 inhibitors (eg ritonavir & itraconazole).

Side Effects

Side effects of Clobetasol Propionate + Salicylic Acid topical : Prolonged usage of large amount of clobetasol propionate can lead to sufficient systemic levels to produce adrenal suppression, Cushing's syndrome, diabetes and hypertension.Dermal and epidermal atrophy esp on the face, steroid purpura

Mode of Action

Clobetasol Propionate high potency corticosteroid. Corticosteroids decrease inflammation by stabilizing leukocyte lysosomal membranes, preventing release of destructive acid hydrolases from leukocytes; inhibiting macrophage accumulation in inflamed areas; reducing leukocyte adhesion to capillary endothelium; reducing capillary wall permeability and edema formation; decreasing complement components; antagonizing histamine activity and release of kinin from substrates; and reducing fibroblast proliferation, collagen deposition, and subsequent scar tissue formation. Salicylic acid has a potent keratolytic action and a slight antiseptic action when applied topically. It softens and destroys the stratum corneum by increasing endogenous hydration which causes the horny layer of the skin to swell, soften, and then desquamate. At high concentrations, salicylic acid has a caustic effect. It also possesses weak antifungal and antibacterial activity.

Note

Topiclo-S .05 gm + 3 gm/100 gm Ointment generic name is Clobetasol Propionate + Salicylic Acid topical. Topiclo-S .05 gm + 3 gm/100 gm Ointment is manufactured by Eskayef Pharmaceuticals Ltd.Topiclo-S is availble in all over Bangladesh. Mes BD drug index information on Topiclo-S Ointment is not intended for diagnosis, medical advice or treatment; neither intended to be a substitute for the exercise of professional judgment.

Some other brands of Clobetasol Propionate + Salicylic Acid topical :

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Ointment

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CREAM

XDERM-S ^{.05 gm + 3 gm/100 gm}

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