Indications
Tergocin Injection is used for:
Gram-positive infection, CAPD-associated peritonitis
Adult Dose
Parenteral
Severe Gram-positive infections
Adult: Initially, 6 mg/kg on first day, followed by 3 mg/kg/day. Severe infection: 6 mg/kg every 12 hr for the 1st 3 doses followed by 6 mg/kg/day. Doses may be given via IM inj, IV bolus or IV infusion over 30 minutes.
Intravenous
Prophylaxis of Gram-positive infection in high-risk patients undergoing surgery
Adult: 400 mg as single dose at induction of anesth.
Continuous ambulatory peritoneal dialysis (CAPD)-associated peritonitis
Adult: If the patient is febrile, an initial loading dose of 400 mg may be given. Teicoplanin is added to the dialysis solution at a concentration of 20 mg/litre; dose is added into each bag of solution in the first wk, followed by alternate bags in the second wk and then in the overnight dwell bag in the third wk.
Child Dose
Parenteral
Severe Gram-positive infections
Child: Loading dose: 10 mg/kg every 12 hr for 3 doses followed by 6-10 mg/kg/day depending on severity of the infection. Neonates: Loading dose: 16 mg/kg on the 1st day, followed by maintenance doses of 8 mg/kg/day by IV infusion.
Renal Dose
Parenteral
Renal impairment: Usual dose to be given for first 3 days, thereafter adjust dose according to CrCl.
CrCl (ml/min) Dosage Recommendation
40-60 1/2 initial dose given daily or initial dose every 2 days.
<40 1/3 initial dose given daily or initial dose every 3 days.
Intravenous
Renal impairment: Dose adjustment may be required.
Administration
Contra Indications
Hypersensitivity.
Precautions
Preexisting renal insufficiency, hypersensitivity to vancomycin. Perform periodic haematological studies, renal, LFT. Pregnancy, lactation.
Pregnancy-Lactation
Interactions
Other nephrotoxic and/or neurotoxic drugs.
Side Effects
Side effects of Teicoplanin :
Fever, chills, allergic reactions, GI disturbances, headache, dizziness, "red-man" syndrome, disturbances in liver enzymes, renal impairment, ototoxicity, blood dyscrasias. Pain, erythema, thrombophloebitis, abscess at site of admin.
Potentially Fatal: Stevens-Johnson syndrome, toxic epidermal necrolysis.
Mode of Action
Glycopeptide antibiotic with spectrum of activity is similar to vancomycin but teicoplanin may be more active in vitro against enterococci and some anaerobic organisms but some coagulase-negative Staphylococci are less sensitive to teicoplanin than to vancomycin.
Note
Tergocin 400 mg/vial Injection generic name is Teicoplanin. Tergocin 400 mg/vial Injection is manufactured by Incepta Pharmaceuticals Ltd.Tergocin is availble in all over Bangladesh.
Mes BD drug index information on Tergocin Injection is not intended for diagnosis, medical advice or treatment; neither intended to be a substitute for the exercise of professional judgment.