Indications
Temixil Tablet is used for:
Insomnia, Premedication in surgery
Adult Dose
Oral
Short-term management of insomnia
Adult: 7.5-30 mg at bedtime for 7-10 days. Max: 40 mg.
Elderly: 5 mg at bedtime. May be increased to 10-20 mg in severe cases.
Hepatic impairment: 5 mg at bedtime. May be increased to 10-20 mg in severe cases.
Severe: Contraindicated.
Premedication in surgery
Adult: 20-40 mg, 30 min to 1 hr before the procedure.
Elderly: 10-20 mg, 1 hr before the procedure.
Hepatic impairment: Severe: Contraindicated.
Child Dose
Safety and efficacy not established
Renal Dose
Insomnia
Renal impairment: 5 mg at bedtime. May be increased to 10-20 mg in severe cases.
Administration
May be taken with or without food. Gradually taper after extended therapy; abrupt discontinuation should be avoided
Contra Indications
Acute pulmonary insufficiency, resp depression, sleep apnoea, obsessional states, myasthenia gravis, severe hepatic impairment. Pregnancy.
Precautions
Patient w/ severe depression, chronic pulmonary insufficiency, personality disorders, history of alcohol or drug addiction. Avoid abrupt withdrawal. Renal and hepatic impairment. Elderly or debilitated patient. Lactation. Patient Counselling May impair ability to perform tasks that require alertness (e.g. driving or operating machinery). Monitoring Parameters Monitor resp and CV status.
Lactation: Avoid if breastfeeding
Pregnancy-Lactation
Pregnancy Category: X
Lactation: Avoid if breastfeeding
Minor tranquilizers should be avoided in 1st trimester of pregnancy due to increased risk of congenital malformations
Maternal use shortly before delivery is associated with floppy infant syndrome (good and consistent evidence)
Prenatal benzodiazepine exposure slightly increased oral cleft risk (limited or inconsistent evidence)
Interactions
May enhance CNS depressant effect w/ Na oxybate, antipsychotics, tranquilisers, neuroleptics, antidepressants, hypnotics, anaesth, analgesics, sedative antihistamines, barbiturates. Effect may be reduced w/ theophylline.
Side Effects
Side effects of Temazepam :
1-10%
Drowsiness (9.1%), Dizziness (4.5%), Lethargy (4.5%), Hangover (2.5%), Diarrhea (1.7%), Euphoria (1.5%), Weakness (1.4%), Confusion (1.3%), Vertigo (1.2%)
< 1%
Amnesia, Angioedema, Blood dyscrasias, Sleep-related behavior (eg, sleep driving, sleep cooking, sleep eating), Ataxia
Mode of Action
Temazepam is a short-acting benzodiazepine w/ anxiolytic, hypnotic/sedative, muscle relaxant properties. It increases neuronal membrane permeability to Cl ions by binding to stereospecific benzodiazepine receptors on the postsynaptic GABA neuron w/in the CNS and enhancing the GABA inhibitory effects resulting in hyperpolarisation and stabilisation.
Note
Temixil 10 mg Tablet generic name is Temazepam. Temixil 10 mg Tablet is manufactured by Renata LimitedTemixil is availble in all over Bangladesh.
Mes BD drug index information on Temixil Tablet is not intended for diagnosis, medical advice or treatment; neither intended to be a substitute for the exercise of professional judgment.