Supraphen PLUS Ear Drops
Chloramphenicol 5% + Lidocaine Hydrochloride 1% Ear drops
500 mg + 100 mg/100 ml
G. A. Company Ltd.
| Pack size | 10 ml drop |
|---|---|
| Unite Price | 20.06 BDT |
Indications
Supraphen PLUS Ear Drops is used for:
Acute bacterial ear infections
Adult Dose
Otic/Aural Otitis externa Adult: Instill 2-3 drops into the ear bid-tid.
Child Dose
Renal Dose
Administration
Contra Indications
History of hypersensitivity or toxic reaction to the drug; Perforated ear drum. Herpes simplex and other virul conditions of the eye or ear, mycosis.
Precautions
Avoid prolonged use. Discontinue immediately if local hypersensitivity reactions occur.
Pregnancy-Lactation
Interactions
Decreased effects of iron and vitamin B12 in anaemic patients. Phenobarbitone and rifampin reduce efficacy of chloramphenicol. Impairs the action of oral contraceptives.
Potentially Fatal: Increases the effect of oral anticoagulants, oral hypoglycaemic agents, phenytoin. Avoid concomitant administration with drugs that depress bone marrow function.
May increase serum levels w/ cimetidine and propranolol. Increased risk of cardiac depression w/ ?-blockers and other antiarrhythmics. Additive cardiac effects w/ IV phenytoin. Hypokalaemia caused by acetazolamide, loop diuretics and thiazides may antagonise effect of lidocaine. Dose requirements may be increased w/ long-term use of phenytoin and other enzyme-inducers.
Side Effects
Side effects of Chloramphenicol 5% + Lidocaine Hydrochloride 1% Ear drops :
Ear drops: Ototoxicity.
Mode of Action
Chloramphenicol inhibits bacterial protein synthesis by binding to 50s subunit of the bacterial ribosome, thus preventing peptide bond formation by peptidyl transferase. It has both bacteriostatic and bactericidal action against H. influenzae, N. meningitidis and S. pneumoniae.
Lidocaine is an amide type local anaesth. It stabilises the neuronal membrane and inhibits Na ion movements, which are necessary for conduction of impulses. In the heart, lidocaine reduces depolarisation of the ventricles during diastole and automaticity in the His-Purkinje system. Duration of action potential and effective refractory period are also reduced.
Note
Supraphen PLUS 500 mg + 100 mg/100 ml Ear Drops generic name is Chloramphenicol 5% + Lidocaine Hydrochloride 1% Ear drops. Supraphen PLUS 500 mg + 100 mg/100 ml Ear Drops is manufactured by G. A. Company Ltd.Supraphen PLUS is availble in all over Bangladesh.
Mes BD drug index information on Supraphen PLUS Ear Drops is not intended for diagnosis, medical advice or treatment; neither intended to be a substitute for the exercise of professional judgment.