Simplovir Cream
Acyclovir 5% Topical
5%
Incepta Pharmaceuticals Ltd.
| Pack size | 5gm tube |
|---|---|
| Unite Price | 40.00 BDT |
Indications
Simplovir Cream is used for:
Herpes virus infections of skin
Adult Dose
As 5% oint/cream: Apply to the affected skin 5-6 times/day for 5-10 days.
Child Dose
Renal Dose
Administration
Contra Indications
Hypersensitivity.
Precautions
Renal impairment. Pregnancy, lactation. Neurological abnormalities with significant hypoxia, serious hepatic or electrolyte abnormalities. Maintain adequate hydration.
Lactation: Excretion in milk unknown; systemic exposure is minimal after topical application.
Pregnancy-Lactation
Pregnancy category: B
Lactation: Excretion in milk unknown; systemic exposure is minimal after topical application
Interactions
Probenecid, cimetidine and mycophenolate mofetil may increase the plasma concentration of aciclovir. Increased nephrotoxic effects w/ drugs that affect renal physiology (e.g. ciclosporin, tacrolimus).
Side Effects
Side effects of Acyclovir 5% Topical :
>10%
Burning/stinging (30%)
1-10%
Pruritus (4%)
<1%
Dry lips (<1%), Rash (0.3%)
Frequency Not Defined
Angioedema, Vulvitis
Mode of Action
Activity against HSV types I and II and varicella-zoster virus is due to intracellular conversion of aciclovir to the monophosphate by viral thymidine kinase with subsequent conversion to the diphosphate and active triphosphate by cellular enzymes. This active form inhibits viral DNA synthesis and replication by interfering with viral DNA polymerase enzyme and being incorporated into viral DNA.
Note
Simplovir 5% Cream generic name is Acyclovir 5% Topical. Simplovir 5% Cream is manufactured by Incepta Pharmaceuticals Ltd.Simplovir is availble in all over Bangladesh.
Mes BD drug index information on Simplovir Cream is not intended for diagnosis, medical advice or treatment; neither intended to be a substitute for the exercise of professional judgment.