Indications
Silosin Capsule is used for:
Treating the signs and symptoms of enlarged prostate (benign prostatic hyperplasia [BPH]).
Adult Dose
Benign Prostatic Hyperplasia
Adults
PO 8 mg once daily with a meal.
Hepatic Impairment
Mild-to-moderate impairment (Child-Pugh class A or B): Dose adjustment not necessary
Severe Impairment: (Child-Pugh class C): Contraindicated (not studied)
Child Dose
Renal Dose
Renal Impairment
CrCl <50 mL/min: Dose adjustment not necessary
CrCl 30-50 mL/min: 4 mg PO qDay
CrCl <30 mL/min: Contraindicated
Administration
Contra Indications
Hypersensitivity.
Precautions
Impaired hepatic & renal function. Start treatment w/ a low dose (2 mg/dose).
Pregnancy-Lactation
Pregnancy Category: B; not indicated in women
Lactation: Unknown if distributed in breast milk; not indicated in women
Interactions
Ketoconazole, digoxin.
Side Effects
Side effects of Silodosin :
>10%
Retrograde ejaculation (28%)
1-10%
Diarrhea (3%), Headache (2%), Insomnia ((1-2%), Dizziness (3%), Orthostatic hypotension (3%; increased in patients >65 years), Nasopharyngitis (2%), Nasal congestion (2%), Sinusitis (1-2%)
Mode of Action
Selectively blocks postsynaptic alpha-1 adrenoreceptors located in the prostate, bladder base, bladder neck, prostatic capsule, and prostatic urethra.
Note
Silosin 4 mg Capsule generic name is Silodosin. Silosin 4 mg Capsule is manufactured by Incepta Pharmaceuticals Ltd.Silosin is availble in all over Bangladesh.
Mes BD drug index information on Silosin Capsule is not intended for diagnosis, medical advice or treatment; neither intended to be a substitute for the exercise of professional judgment.