Sebivo Tablet
Telbivudine
600mg
Novartis Pharma AG, Switzerland
| Pack size | 28's pack |
|---|---|
| Unite Price | 313.68 BDT |
Indications
Sebivo Tablet is used for:
Chronic hepatitis B
Adult Dose
Oral
Chronic hepatitis B
Adult: 600 mg once daily.
Child Dose
Safety and efficacy not established
Child: >16 yr: 600 mg once daily.
Renal Dose
Renal impairment: ESRD: 600 mg 96 hrly, after dialysis session.
CrCl (ml/min) Dosage Recommendation
<30 (not requiring dialysis) 600 mg 72 hrly.
30-49 600 mg 48 hrly.
Administration
May be taken with or without food.
Contra Indications
Hypersensitivity. Lactation. Concurrent use w/ peginterferon alfa-2a.
Precautions
Patient w/ cirrhosis, hepatomegaly or other risk factors for liver disease. Renal impairment. Pregnancy. Monitoring Parameters Monitor hepatic function (e.g. AST and ALT) periodically during therapy and for several mth following discontinuation of therapy; renal function; signs and symptoms of peripheral neuropathy or myopathy; serum creatine kinase; hepatitis B virus (HBV) DNA 3-6 mthly during therapy; HBeAg and anti-HBe signs/symptoms of HBV relapse/exacerbation after discontinuation of therapy.
Lactation: not known if distributed in breast milk, do not nurse
Pregnancy-Lactation
Pregnancy Category: B
Lactation: not known if distributed in breast milk, do not nurse
Interactions
Increased risk of peripheral neuropathy when used with peginterferon alfa-2a.
Side Effects
Side effects of Telbivudine :
>10%
Fatigue (13%), Elevated serum creatinine kinase (11%);
1-10%
Headache (10%), Cough (6%), Diarrhea (6%), Abdominal pain, upper (6%), Nausea (5%), Pharyngolaryngeal pain (5%), Arthralgia (4%), Pyrexia (4%), Rash (4%), Back pain (4%), Dizziness (4%), Abdominal pain (3%), Myalgia (3%), ALT increased (3%), Dyspepsia (3%), Insomnia (3%), Abdominal distension (3%), Pruritus (2%), Hepatitis B exacerbation (2%)
<1%
Peripheral neuropathy, Myopathy/myositis
Potentially Fatal: Lactic acidosis and severe hepatomegaly.
Mode of Action
Telbivudine is a synthetic thymidine nucleoside analogue. It undergoes intracellular phosphorylation to form its active metabolite, telbivudine triphosphate. Telbivudine triphosphate inhibits hepatitis B viral DNA polymerase; enzyme inhibition blocks reverse transcriptase thus reducing viral DNA replication. It is used in the treatment of chronic hepatitis B infection.
Note
Sebivo 600mg Tablet generic name is Telbivudine. Sebivo 600mg Tablet is manufactured by Novartis Pharma AG, SwitzerlandSebivo is availble in all over Bangladesh.
Mes BD drug index information on Sebivo Tablet is not intended for diagnosis, medical advice or treatment; neither intended to be a substitute for the exercise of professional judgment.