Rotarix Oral Vaccine
Rota Virus Live attenuated Oral Vaccine
1.5 ml
GlaxoSmithkline Biologicals S.A,Belgium
| Pack size | 1 ml vial with oral applicator |
|---|---|
| Unite Price | 1474.00 BDT |
Indications
Rotarix Oral Vaccine is used for:
Prevention of Rotavirus diarrhea
Adult Dose
Child Dose
2-Dose Regimen
Prevention of rotavirus gastroenteritis
Total of two 1 ml doses administered orally
Administer first dose to infants beginning at 6 weeks of age
Administer second dose after an interval of at least 4 weeks and prior to 24 weeks of age
Renal Dose
Administration
May be taken with or without food.
Contra Indications
Subjects with history of intussusception. Subjects with Severe Combined Immunodeficiency (SCID) disorder The presence of a minor infection, such as a cold, is not a contraindication for immunisation.
Precautions
History of GI disorders including chronic GI disorders, chronic diarrhoea, congenital abdominal disorders, abdominal surgery; growth retardation. Defer admin in infants suffering from acute diarrhoea, vomiting or severe acute febrile illness. Monitor infant after vaccination for signs of intussusceptions (e.g. severe abdominal pain, persistent vomiting, bloating, blood in stools, and/or high fever) or Kawasaki disease (E.g fever, skin rash, red eyes, red mouth, swollen hands and feet, swollen gland). Use with caution in presence of non-vaccinated or immunodeficient contacts due to a theoretical risk of live vaccine virus transmission via excretion in the stool. Use in immunocompromised/potentially immunocompromised infants or post-exposure prophylaxis have not been evaluated.
Pregnancy-Lactation
Interactions
Immunosuppressive therapies may diminish a patient's immune response to the vaccine. Simultaneous immunisation with other age-appropriate vaccines including live virus vaccines, toxoids, inactivated or recombinant vaccines is not expected to interfere with the immunologic responses to the vaccine.
Side Effects
Side effects of Rota Virus Live attenuated Oral Vaccine :
>10%
Diarrhea (24.1%), Vomiting (15.2%), Otitis media (14.5%), Fever (17-43%), Fussiness/irritability (3-52%)
1-10%
Nasopharyngitis (6.9%), Bronchospasm (1.1%), Faltulence (2%)
Mode of Action
Rotavirus is one of the important causes of severe acute gastroenteritis in infants and young children. There are 2 commercially available forms of rotavirus vaccine. A live, attenuated monovalent vaccine derived from human strain indicated for prevention of rotavirus gastroenteritis caused by G1, G3, G4 and G9 serotypes; Human Rota Virus, Live attenuated Vaccine as a live, pentavalent human-bovine reassortant vaccine indicated for prevention of gastreoenteritis caused by rotavirus serotypes G1, G2, G3 and G4. Although presence of porcine cirovirus (PCV1 and PCV2) DNA have been detected in the rotavirus vaccine, current available information shows that there is no evidence that PCV1 or PCV2 poses a safety risk to humans. Exact immunologic mechanism of action is not fully understood although it is known that vaccine viruses replicate in the small intestine and promote active immunity.
Note
Rotarix 1.5 ml Oral Vaccine generic name is Rota Virus Live attenuated Oral Vaccine. Rotarix 1.5 ml Oral Vaccine is manufactured by GlaxoSmithkline Biologicals S.A,BelgiumRotarix is availble in all over Bangladesh.
Mes BD drug index information on Rotarix Oral Vaccine is not intended for diagnosis, medical advice or treatment; neither intended to be a substitute for the exercise of professional judgment.