Pyrison Tablet
Pyrimethamine
25mg
Jayson Pharmaceuticals Ltd.
| Pack size | 100's pack |
|---|---|
| Unite Price | 28 BDT |
Indications
Pyrison Tablet is used for:
Acute malaria, Malaria prophylaxis, Toxoplasmosis
Adult Dose
Oral
Acute malaria
Adult: As a single dose, in combination with a sulfonamide: 75 mg pyrimethamine with 1.5 g sulfadoxine.
Prophylaxis of malaria
Adult: Pyrimethamine 25 mg as single dose once wkly. 1st dose should be taken 1-2 days before arrival in the endemic area, continue admin during stay and for 4-6 wk after leaving the area.
Toxoplasmosis
Adult: 50-75 mg pyrimethamine daily with 1-4 g sulfadiazine daily. Continue at this dosage for 1-3 wk, depending on the patient's response and tolerance, then half the dosage and continue for another 4-5 wk.
Child Dose
Oral
Acute malaria
Child: 7-13 yr: 50 mg pyrimethamine with 1 g sulfadoxine;
1-6 yr: 25 mg pyrimethamine with 500 mg sulfadoxine;
5-11 mth: 12.5 mg pyrimethamine and 250 mg sulfadoxine.
To be taken as a single dose, in combination with a sulfonamide.
Prophylaxis of malaria
Child: <4 yr: 6.25 mg once wkly;
4-10 yr: 12.5 mg once wkly;
>10 yr: 25 mg once wkly.
1st dose should be taken 1-2 days before arrival in the endemic area, continue admin during stay and for 4-6 wk after leaving the area.
Congenital Toxoplasmosis
>2 Months Old
Loading dose: 2 mg/kg/day divided q12hr PO for 2 days
Maintenance.: First 2-6 months old: 1 mg/kg PO qD for 2-6 months old; THEN remainder of 12 months old; 1 mg/kg PO 3 times/week
Toxoplasmosis
Loading dose: 2 mg/kg/d divided q12hr PO for 3 days
Maintenance: 1 mg/kg PO qD for 4 weeks
< 2 months old: Safety and efficacy not established
Renal Dose
Administration
Should be taken with food.
Contra Indications
Hypersensitivity, resistant malaria, megaloblastic anaemia secondary to folate deficiency. Pregnancy and lactation.
Precautions
Renal or hepatic impairment; folate deficiency; monitor blood and platelet counts every 2 wk with prolonged treatment and large doses. Discontinue use if skin reactions, sore throats or shortness of breath occurs.
Lactation: enters breast milk, do not nurse
Pregnancy-Lactation
Pregnancy Category: C
Lactation: enters breast milk, do not nurse
Interactions
Lorazepam may induce hepatotoxicity. Increased risk of bone marrow suppression when used with agents that have myelosuppressive properties e.g. proguanil, sulfonamides, zidovudine and cytostatic agents. Increased risk of serious pancytopenia and megaloblastic anaemia when used with co-trimoxazole or other sulfonamides.
Side Effects
Side effects of Pyrimethamine :
Rashes, macrocytic anaemia (high dose), leucopenia, thrombocytopenia, megaloblastic anaemia, pancytopenia, abdominal pain, vomiting, atrophic glossitis.
Depression, Fever, Insomnia, Lightheadedness, Malaise, Seizures, Dermatitis, Erythema multiforme
Potentially Fatal: Cutaneous reactions e.g. erythema multiforme and Stevens-Johnson syndrome and toxic epidermal necrolysis with sulfadoxine at large doses.
Mode of Action
Pyrimethamine is a folic acid antagonist structurally similar to trimethoprim. It inhibits parasitic dihydrofolate reductase, thus inhibiting vital tetrahydrofolic acid synthesis. It is active against pre-erythrocytic forms and is also a slow-acting schizontocide.
Note
Pyrison 25mg Tablet generic name is Pyrimethamine. Pyrison 25mg Tablet is manufactured by Jayson Pharmaceuticals Ltd.Pyrison is availble in all over Bangladesh.
Mes BD drug index information on Pyrison Tablet is not intended for diagnosis, medical advice or treatment; neither intended to be a substitute for the exercise of professional judgment.