Prosulf Ampoules
Protamine Sulfate
10mg/ml
Radiant Pharmaceutical Ltd.
| Pack size | 10's Pack |
|---|---|
| Unite Price | 170.00 BDT |
Indications
Prosulf Ampoules is used for:
Heparin overdosage, Dalteparin or Tinzaparin Overdose, Enoxaparin Overdose
Adult Dose
Intravenous
Heparin overdosage
Adult:
1-1.5 mg per 100 USP units of heparin; not to exceed 50 mg
Monitor APTT 5-15 min after dose then in 2-8 hr
In accidental overdoses of heparin, consider t1/2 heparin 60-90 min
In setting without bleeding complications, consider observation, rather than reversal of anticoagulation with protamine (avoids ADR's)
Complex of protamine and heparin may degrade over time requiring further doses
Dalteparin or Tinzaparin Overdose
1 mg protamine for 100 units dalteparin or tinzaparin; if PTT prolonged 4hr after protamine overdose administer 0.5 mg per 100 units of dalteparin or tinzaparin
Enoxaparin Overdose
1 mg per mg enoxaparin (if enoxaparin overdose given within 8 hr); if >8 hr of overdose or bleeding continues after 4 hr after first dose, give 0.5 mg protamine per mg enoxaparin
Time Elapsed Since Heparin Dose
Dose of protamine (mg) to neutralize 100 units of heparin
<1/2 hr: 1-1.5 mg/100 units of heparin
30-120 min: 0.5-0.75 mg/100 units of heparin
>2 hr: 0.25-0.375 mg/100 units of heparin
Child Dose
Renal Dose
Administration
IV Preparation
Reconstitute with 5 mL sterile water
Resulting solution equals 10 mg/mL
IV Administration
Inject without further dilution over 1-3 min; maximum of 50 mg in any 10 min period
For IV use only
Administer slow IVP (50 mg over 10 min)
Rapid IV infusion causes hypotension
Contra Indications
Hypersensitivity
Precautions
Patient at risk of developing hypersensitivity to protamine (e.g. previous history of procedures such as coronary angioplasty or cardiopulmonary bypass surgery where protamine is frequently used, diabetics using protamine insulin, allergy to fish, vasectomised or infertile males who may have antibodies to protamine). Pregnancy and lactation.
Protamine sulfate can cause severe hypotension, cardiovascular collapse, noncardiogenic pulmonary edema, catastrophic pulmonary vasoconstriction, and pulmonary hypertension
Pregnancy-Lactation
Pregnancy Category: C
Lactation: not known if excreted in breast milk
Interactions
Side Effects
Side effects of Protamine Sulfate :
Frequency Not Defined
Anaphylaxis
Hypotension
N/V
Decreased O2 consumption
Flushing
Pulmonary hypertension
Uncontrollable bleeding
Circulatory collapse
Pulmonary edema
Mode of Action
Protamine sulfate is prepared from the sperm or mature testes of salmon or related species and is composed of arginine, proline, serine and valine. It combines w/ strongly acidic heparin to form a stable complex, neutralising the anticoagulant activity of both drugs.
Note
Prosulf 10mg/ml Ampoules generic name is Protamine Sulfate. Prosulf 10mg/ml Ampoules is manufactured by Radiant Pharmaceutical Ltd.Prosulf is availble in all over Bangladesh.
Mes BD drug index information on Prosulf Ampoules is not intended for diagnosis, medical advice or treatment; neither intended to be a substitute for the exercise of professional judgment.