Prolific Injection

Chorionic Gonadotrophin

5000 IU/vial

Renata PLC.

Pack size	5000 IU vial
Unite Price	2000.00 BDT

Indications

Prolific Injection is used for: Anovulatory infertility, Adjunct to IVF procedures and other assisted conception techniques

Adult Dose

Intramuscular Prepubertal cryptorchidism in males Adult: 500-4000 u injected 3 times wkly. Treatment should continue for 1-2 mth after testicular descent. Male infertility due to hypogonadotrophic hypogonadism Adult: 500-4000 u injected 2-3 times wkly. Anovulatory infertility Adult: Single dose of 5000-10,000 u. Up to 3 repeated injections of up to 5000 u each may be given within the following 9 days to prevent corpus luteum insufficiency. Delayed puberty associated with hypogonadism in males Adult: Male: Initially, 500-1500 u twice a wk titrated against plasma-testosterone concentration.

Child Dose

Renal Dose

Administration

Contra Indications

Hypersensitivity; precocious puberty, prostatic carcinoma or other androgenic dependent neoplasm. Pregnancy and lactation.

Precautions

Discontinue therapy if signs of precocious puberty are seen in patients treated for cryptorchidism. Patients with cardiac or renal disease, epilepsy, migraine or asthma.

Pregnancy-Lactation

Interactions

Interactions of Human chorionic gonadotrophin with other medicines have not been investigated; interactions with commonly used medicinal products cannot be excluded. Following administration, Human chorionic gonadotrophin may interfere for up to 10 days with the immunological determination of serum/urinary human chorionic gonadotropin (hCG), leading to a false positive pregnancy test. Incompatibilities: In the absence of compatibility studies, Pregnyl must not be mixed with other medicinal products.

Side Effects

Side effects of Chorionic Gonadotrophin : Headache, irritability, restlessness, depression, fatigue, oedema; precocious puberty, gynaecomastia; pain at Inj site; enlargement of preexisting ovarian cysts and possible rupture; arterial thromboembolism; shock; abdominal pain. Potentially Fatal: Ovarian hyperstimulation syndrome (OHSS).

Mode of Action

Chorionic Gonadotrophin is a polypeptide hormone produced by the human placenta. It stimulates the production of gonadal steroid hormones by inducing interstitial cells (Leydig cells) of the testis to produce androgens and the corpus luteum of the ovary to produce progesterone.

Note

Prolific 5000 IU/vial Injection generic name is Chorionic Gonadotrophin. Prolific 5000 IU/vial Injection is manufactured by Renata PLC.Prolific is availble in all over Bangladesh. Mes BD drug index information on Prolific Injection is not intended for diagnosis, medical advice or treatment; neither intended to be a substitute for the exercise of professional judgment.

Some other brands of Chorionic Gonadotrophin :

IM Injection

HCG 5000 ^5000IU

Popular Pharmaceuticals Ltd.

IM Injection

HCG 10000 ^{10000 IU}

Popular Pharmaceuticals Ltd.

Vials

Choriofactor ^{5000 IU/Vial Lyophilized}

ZAS Corporation

IM/SC Injection

Pregnyl ^{5000 IU/vial}

Healthcare Pharmaceuticals Ltd.

IM/SC Injection

HCG ^{2500 IU/vial}

Popular Pharmaceuticals Ltd.