Profenid Gel
Ketoprofen 2.5% Topical
2.5%
Synovia Pharma PLC.
| Pack size | 30gm Tube |
|---|---|
| Unite Price | 120.36 BDT |
Indications
Profenid Gel is used for:
Rheumatic disorders, Musculoskeletal pain, Pain and inflammation
Adult Dose
Topical/Cutaneous
Local pain relief
Adult: As 2.5% gel: Apply onto affected areas 2-4 times daily for up to 10 days. As 30 mg plaster: Apply 1 plaster bid.
Child Dose
Renal Dose
Administration
Contra Indications
For all routes: Hypersensitivity to aspirin or other NSAIDs or those suffering from asthma, angioedema, urticaria or rhinitis. Active GI disease (e.g. bleeding or ulcer). Severe heart failure, and renal insufficiency. Treatment of perioperative pain in the setting CABG surgery. Rectal: Patients w/ history of proctitis or haemorrhoids.
Precautions
History of GI disease (e.g. bleeding or ulcer). Hypertensive patients; renal or hepatic impairment. Pregnancy, lactation, elderly. Monitoring Parameters Close monitoring of BP during initiation and throughout the therapy. Complete blood cell count, chemistry profile, liver and renal function test performed periodically for patients receiving long-term ketoprofen therapy.
Pregnancy-Lactation
Pregnancy Category: B; D in 3rd trimester or near delivery.
Interactions
Increases plasma concentrations of lithium and methotrexate. Reduces effects of antihypertensives (e.g. ACE inhibitors, angiotensin II receptor antagonists). Increased risk of GI bleeding w/ warfarin. Decreased protein binding of ketoprofen and increased risk for serious GI events w/ aspirin and other NSAIDs. Increased risk of developing renal failure w/ diuretics. Increased risk of GI bleeding and ulceration w/ corticosteroids. Increased plasma levels w/ probenecid. Salicylate reduces conjugation and renal elimination of ketoprofen.
Side Effects
Side effects of Ketoprofen 2.5% Topical :
HTN; GI symptoms e.g. dyspepsia, discomfort, nausea, diarrhoea; pain and tissue damage at inj site (IM). Cardiovascular toxicity (chest pain, dyspnea, weakness, slurred speech). May mask the usual signs and symptoms of infection. NSAID-induced liver dysfunction, anaphylactoid reaction (e.g. difficulty breathing, swelling of the face or throat); photosensitivity reactions (topical).
Mode of Action
Ketoprofen exhibits anti-inflammatory, analgesic and antipyretic properties. It potently inhibits the enzyme cyclooxygenase resulting in prostaglandin synthesis inhibition.
Note
Profenid 2.5% Gel generic name is Ketoprofen 2.5% Topical. Profenid 2.5% Gel is manufactured by Synovia Pharma PLC.Profenid is availble in all over Bangladesh.
Mes BD drug index information on Profenid Gel is not intended for diagnosis, medical advice or treatment; neither intended to be a substitute for the exercise of professional judgment.