Presart 20 Tablet
Telmisartan
20 mg
General Pharmaceuticals Ltd.
| Pack size | 30's Pack |
|---|---|
| Unite Price | 7.00 BDT |
Indications
Presart 20 Tablet is used for:
Hypertension in adults, Reduction of cardiovascular morbidity in adults with atherothrombotic cardiovascular disease, (history of coronary heart disease, stroke, or peripheral arterial disease), Type 2 diabetes mellitus, with documented target organ damage.
Adult Dose
Oral
Hypertension
Adult: Dosage must be individualized.
The usual starting dose of Telmisartan tablets is 40 mg once a day.
Blood pressure response is dose-related over the range of 20 to 80 mg.
Most of the anti hypertensive effect is apparent within 2 weeks and maximal reduction is generally attained after 4 weeks.
When additional blood pressure reduction beyond that achieved with 80 mg Telmisartans is required, may switch to combination, a diuretic may be added.
Telmisartan tablets may be administered with other antihypertensive agents.
Initial therapy with Telmisartan is not recommended in patients >75 years old or with hepatic impairment
Elderly: No initial dosage adjustment is necessary for elderly patients.
Cardiovascular risk reduction
Adult:The recommended dose of telmisartan tablets is 80 mg once a day.
It is not known whether doses lower than 80 mg of telmisartan are effective in reducing the risk of cardiovascular morbidity and mortality.
When initiating telmisartan therapy for cardiovascular risk reduction, monitoring of blood pressure is recommended, and if appropriate, adjustment of medications that lower blood pressure may be necessary.
Hepatic impairment: Initial therapy with telmisartan is not recommended in patients ?75 years old or with hepatic impairment.
Child Dose
<18 years old: Safety and efficacy not established
Renal Dose
Renal impairment:
No initial dosage adjustment is required for patients with mild to moderate renal impairment. Titrate slowly in patients with severe renal impairment.
Patients on dialysis may develop orthostatic hypotension; their blood pressure should be closely monitored.
Administration
May be taken with or without food.
Contra Indications
Severe hepatic impairment, biliary obstructive disorders. Pregnancy. Lactation.
Precautions
Avoid fetal or neonatal exposure, Hypotension, Monitor carefully in patients with impaired hepatic or renal function, Avoid concomitant use of an ACE inhibitor and angiotensin receptor blocker.
Hepatic insufficiency, biliary obstruction, renal impairment, renaly artery stenosis. Correct volume depletion before initiating treatment. Monitor serum potassium levels regularly, especially in elderly and renally-impaired patients.
Pregnancy-Lactation
Pregnancy category: 1st trimester, C; 2nd and 3rd trimesters, D
Lactation: Not known whether drug is excreted in breast milk; avoid using
Interactions
May increase plasma levels of digoxin. May increase serum lithium levels and toxicity. May reduce plasma levels of warfarin. Increased risk of hyperkalaemia w/ K-sparing diuretics, K supplements or K-containing salt substitutes. May antagonise hypotensive effect and increase risk of renal impairment w/ NSAIDs.
Potentially Fatal: May increase nephrotoxic, hyperkalaemic and hypotensive effect w/ aliskiren in patients w/ diabetes and renal impairment (GFR <60 mL/min).
Side Effects
Side effects of Telmisartan :
1-10%
Upper respiratory tract infection (URTI) (7%), Back pain (3%), Diarrhea (3%), Myalgia (3%), Sinusitis (3%), Chest pain (1%), Hypertension (1%), Headache (1%), Dizziness (1%), Pharyngitis (1%)
<1%
Abnormal ECG, Anemia, Angina, Angioedema, Bradycardia, Eczema, Epistaxis, Gout, Hypercholesterolemia, Hyperkalemia, Hypoglycemia, Otitis media
Potentially Fatal: Rarely angioedema, rash, pruritus and urticaria.
Mode of Action
Telmisartan blocks the vasoconstrictor and aldosterone-secreting effects of angiotensin II by selectively blocking the binding of angiotensin II to the AT1 receptor in many tissues, such as vascular smooth muscle and the adrenal gland. Its action is therefore independent of the pathways for angiotensin II synthesis.
Note
Presart 20 20 mg Tablet generic name is Telmisartan. Presart 20 20 mg Tablet is manufactured by General Pharmaceuticals Ltd.Presart 20 is availble in all over Bangladesh.
Mes BD drug index information on Presart 20 Tablet is not intended for diagnosis, medical advice or treatment; neither intended to be a substitute for the exercise of professional judgment.