Indications
Pleflacine Tablet is used for:
Susceptible infections, Gonococcal urethritis, Acute uncomplicated cystitis
Adult Dose
Oral
Susceptible infections
Adult: 400 mg bid.
Acute uncomplicated cystitis in women; Gonococcal urethritis in men
Adult: 800 mg as single dose.
IV Influsion
Adult: 400 mg in 100 or 250 ml of 5% dextrose slow infusion over an hour bid.
Child Dose
Renal Dose
Renal impairment: Dose reduction may be necessary.
Administration
Should be taken with food. Take w/ meals.
Contra Indications
Hypersensitivity to quinolones, children <12 yr, pregnancy, lactation.
Precautions
Underlying CNS disease; hepatic disease; renal impairment. Avoid sun exposure, may cause severe sunburn.
Pregnancy-Lactation
Interactions
Reduced absorption with antacids, didanosine (DDI), iron salts, pirenzepine, sucralfate, vincristine, zinc salts; increased levels with cimetidine, probenecid, theophylline; increases the levels of cyclosporine; causes seizures with foscarnet, NSAIDs, piroxicam; hypoglycemia with glimeperide; antagonistic with quercetin.
Side Effects
Side effects of Pefloxacin :
Nausea, vomiting, gastric pain, dizziness, insomnia, allergic skin reactions, thrombocytopaenia, leukopenia/neutropenia, photosensitisation, arthropathy, muscular pain, headache, delusions, depression, hallucinations, hepatic dysfunction.
Mode of Action
Pefloxacin is a fluoroquinolone antibacterial that exhibits its bactericidal action by inhibition of DNA gyrase and topoisomerase IV which are needed for bacterial DNA reproduction.
Note
Pleflacine 400mg Tablet generic name is Pefloxacin. Pleflacine 400mg Tablet is manufactured by Synovia Pharma PLC.Pleflacine is availble in all over Bangladesh.
Mes BD drug index information on Pleflacine Tablet is not intended for diagnosis, medical advice or treatment; neither intended to be a substitute for the exercise of professional judgment.