Pilogen Tablet
Pilocarpine Hydrochloride
5mg
Aristopharma Limited
| Pack size | 30's pack |
|---|---|
| Unite Price | 10.00 BDT |
Indications
Pilogen Tablet is used for:
Dry mouth, Sjogren's syndrome
Adult Dose
Oral
Dry mouth after radiotherapy for malignant neoplasms of the head and neck
Adult: Initially, 5 mg tid. If necessary, increase dose gradually after 4 wk until adequate response is achieved. Max: 10 mg tid.
Hepatic impairment: Reduce dose in moderate to severe cirrhosis.
Oral
Sjogren's syndrome
Adult: For dry eyes and mouth: 5 mg 4 times daily. Max: 30 mg daily. Stop treatment if no improvement after 3 mth.
Hepatic impairment: Reduce dose in moderate to severe cirrhosis.
Child Dose
Renal Dose
Administration
May be taken with or without food.
Contra Indications
Angle-closure glaucoma; acute iritis, anterior uveitis; hypersensitivity. Pregnancy.
Precautions
CVD, cholelithiasis, biliary tract dz, COPD, chronic bronchitis, concomitant use of beta adrenergic agonist, renal insufficiency, PUD, Parkinson's, hyperthyroidism, urinary tract obstruction
Lactation: unknown if drug is distributed into breast milk; use caution
Pregnancy-Lactation
Pregnancy Category: C
Lactation: Excretion in breast milk unknown; use with caution
Interactions
Concomitant admin of 2 miotics may increase risk of toxic reactions. Aminoglycosides, clindamycin, colistin, cyclopropane and halogenated inhalational anaesthetics, quinine, procainamide, lithium and beta-blockers may reduce the efficacy of pilacarpine. Concurrent use with beta-blockers may lead to bradycardia. May prolong the action of suxamethonium.
Potentially Fatal: Miotic and ocular hypotensive effect antagonised by anticholinergics. Conduction disturbances with beta-blockers.
Side Effects
Side effects of Pilocarpine Hydrochloride :
>10%
Sweating (29%), Headache (15%), Flushing (8-13%), Chills (3-15%)
1-10%
Nervousness (10%), Nausea (6%), Dizziness (>3%), Asthenia (>3%)
Frequency Not Defined
Confusion, Hypotension, Hypertension, Bradycardia, Tachycardia, Increased airway resistance, Abdominal cramping, Diarrhea, Urinary frequency, Bladder tightness, Decreased visual acuity
Mode of Action
Cholinergic parasympathomimetic with predominant muscarinic action; increases secretion of exocrine glands (sweat, lacrimal, salivary, intestinal, pancreatic glands, and mucous cells of the respiratory tract may be stimulated.
Tone and mobility of gallbladder, biliary duct, and urinary tract may be increased
Pilocarpine directly stimulates cholinergic receptors in the eyes causing pupillary constriction, spasm of accommodation and a transient rise in IOP followed by a fall.
Note
Pilogen 5mg Tablet generic name is Pilocarpine Hydrochloride. Pilogen 5mg Tablet is manufactured by Aristopharma LimitedPilogen is availble in all over Bangladesh.
Mes BD drug index information on Pilogen Tablet is not intended for diagnosis, medical advice or treatment; neither intended to be a substitute for the exercise of professional judgment.