Phenergan Tablet
Promethazine Hydrochloride
25mg
Synovia Pharma PLC.
| Pack size | 250's pack |
|---|---|
| Unite Price | BDT |
Indications
Phenergan Tablet is used for:
Allergic conditions, Nausea and vomiting, Motion sickness, Insomnia
Adult Dose
Oral
Allergic conditions
Adult: As promethazine HCl: 25 mg at night, increase to 25 mg bid if necessary. Alternatively, 10-20 mg 2-3 times daily.
Prophylaxis of motion sickness
Adult: As promethazine HCl: 20 mg or 25 mg the night before travelling, followed by a similar dose the following morning if necessary. As promethazine teoclate: 25 mg given on the night or 1-2 hr before travelling.
Short-term management of insomnia
Adult: As promethazine HCl: 20-50 mg at night.
Parenteral
Allergic conditions; Sedation
Adult: As promethazine HCl: 25-50 mg, by deep IM, IV inj or IV infusion at a rate of not more than 25 mg/min. Max: 100 mg.
Nausea and vomiting
Adult: As promethazine HCl: 12.5-25 mg, repeated at intervals of not less than 4 hr. Max: 100 mg daily.
Child Dose
Oral
Allergic conditions
Child: As promethazine HCl:
2-5 yr 5-15 mg daily in 1 or 2 divided doses;
>5-10 yr 10-25 mg daily in 1 or 2 divided doses.
Prophylaxis of motion sickness
Child: As promethazine HCl:
2-5 yr 5 mg;
>5-10 yr 10 mg. Doses are given the night before the journey and repeated on the following morning (6-8 hr later) if necessary.
Short-term management of insomnia
Child: As promethazine HCl:
2-5 yr 15-20 mg;
>5-10 yr 20-25 mg.
Parenteral
Allergic conditions; Sedation
Child: As promethazine HCl: 5-10 yr 6.25-12.5 mg by deep IM.
Renal Dose
Renal impairment: Dose reduction may be required.
Administration
May be taken with or without food.
Contra Indications
Patients in coma or suffering from CNS depression of any cause. Childn <2 yr. SC and intra-arterial admin. Concurrent use w/ or w/in 14 days of MAOI use.
Precautions
Patient w/ asthma, bronchitis or bronchiectasis; severe coronary artery disease, narrow-angle glaucoma, epilepsy, bladder neck or pyloro-duodenal obstruction, Reye's syndrome, bone marrow depression, Hepatic and renal impairment. Pregnancy and lactation. Patient Counselling This drug may cause marked drowsiness, if affected, do not drive or operate machinery. Avoid prolonged exposure to sunlight. Monitoring Parameters Monitor mental status; signs and symptoms of tissue injury (IV inj).
Lactation: Not known whether drug crosses into breast milk; discontinue drug, or do not nurse
Pregnancy-Lactation
Pregnancy category: C
Lactation: Not known whether drug crosses into breast milk; discontinue drug, or do not nurse
Interactions
Masks ototoxicity of aminoglycoside antibiotics. May enhance the sedative effects of CNS depressants like alcohol, hypnotics, barbiturates and opioids.
Potentially Fatal: Ventricular arrhythmias when used with drugs that prolong QT interval. Increased risk of extrapyramydal effects w/ MAOIs.
Side Effects
Side effects of Promethazine Hydrochloride :
Neuroleptic Malignant Syndrome (NMS); CV effects (e.g. bradycardia, tachycardia, transient HTN, hypotension; jaundice, blood dyscrasias, extrapyramidal effects; IV inj: Severe tissue injury (e.g. gangrene), pain and burning, paralysis, thrombophlebitis, severe spasm of distal vessels, necrosis. Sedation, Confusion, Disorientation, Blurred vision, Hallucinations, Dystonias, Catatonic states, Euphoria, Excitation, Impotence, Urinary retention
Potentially Fatal: Resp depression and apnoea esp in childn.
Mode of Action
Promethazine, a phenothiazine derivative, blocks postsynaptic dopaminergic receptors in the brain and has a strong alpha-adrenergic blocking effect. It competitively binds to H1-receptors.
Note
Phenergan 25mg Tablet generic name is Promethazine Hydrochloride. Phenergan 25mg Tablet is manufactured by Synovia Pharma PLC.Phenergan is availble in all over Bangladesh.
Mes BD drug index information on Phenergan Tablet is not intended for diagnosis, medical advice or treatment; neither intended to be a substitute for the exercise of professional judgment.