Perinase Nasal Spray
Fluticasone Propionate Nasal prep
50mcg/ Spray
Beximco Pharmaceuticals Ltd.
| Pack size | 120 dose ( spray) unit |
|---|---|
| Unite Price | 250.00 BDT |
Indications
Perinase Nasal Spray is used for:
Seasonal and Perennial allergic and nonallergic, rhinitis, Nasal polyps
Adult Dose
Nasal
Allergic rhinitis
Adults: 2 sprays(100mcg) in each nostril once a day, preferably in the morning. In some cases 2 sprays into each nostril twice daily, not exceeding 4 sprays.
Nasal polyps
Adult: 4 sprays (200 mcg) into each nostril 1-2 times daily for at least 4-6 wk.
Child Dose
Nasal
Allergic rhinitis
Children over 12 years: 2 sprays(100mcg) in each nostril once a day, preferably in the morning. In some cases 2 sprays into each nostril twice daily, not exceeding 4 sprays.
Children under 12 years (4 - 11 Years): 1 spray (50mcg) in each nostril once a day. The maximum total daily dosage should not exceed 4 sprays.
Nasal polyps
Child: >16 yr 4 sprays (200 mcg) into each nostril 1-2 times daily for at least 4-6 wk.
Renal Dose
Administration
Contra Indications
Hypersensitivity.
Precautions
Rarely, immediate hypersensitivity reactions or contact dermatitis may occur after the administration of Fluticasone Propionate nasal spray. Rare instances of wheezing, nasal septum perforation, cataracts, glaucoma and increased intraocular pressure have been reported following the intranasal application of corticosteroids, including Fluticasone Propionate. Although systemic effects have been minimal with recommended doses of Fluticasone Propionate nasal spray, potential risk increases with larger doses. Therefore, larger than recommended doses of Fluticasone Propionate nasal spray should be avoided.
Lactation: Unknown whether distributed in breast milk; caution advised
Pregnancy-Lactation
Pregnancy
Available data on inhaled or intranasal fluticasone propionate use in pregnant women have not reported a clear association with adverse developmental outcomes
Fluticasone propionate crossed the placenta following subcutaneous administration to mice and rats and oral administration to rabbits
Lactation
There are no available data on fluticasone propionate in human milk, effects on breastfed child, or effects on milk production
Developmental and health benefits of breastfeeding should be considered and adverse effects on breastfed child from treatment or from an underlying maternal condition
Interactions
May lead to increased plasma concentrations of fluticasone when used with CYP4503A4 inhibitors such as ritonavir.
Side Effects
Side effects of Fluticasone Propionate Nasal prep :
>10%
Headache (17%), URI (15%)
1-10%
Nasal congestion (8%), Pharyngitis (6-8%), Asthma symptoms (3-7%), Fever (1-5%), Dysphonia (4%), Cough (3-4%), Nasal discharge (1-3%), Aches and pains (1-3%), Flu-like syndrome (1-3%), Bronchitis (1-3%), Diarrhea (1-3%), Abdominal pain (1-3%), Nasal ulcer (1%)
Frequency Not Defined
Loss of taste
With the nasal spray, drying of the nose and an increase in the incidence of nosebleeds may occur.
Potentially Fatal: Paradoxical bronchospasm.
Mode of Action
Fluticasone utilises a fluorocarbothioate ester linkage at the C17 position. It has potent vasoconstrictive and anti-inflammatory activity, but weak HPA inhibitory effect when applied topically.
Note
Perinase 50mcg/ Spray Nasal Spray generic name is Fluticasone Propionate Nasal prep. Perinase 50mcg/ Spray Nasal Spray is manufactured by Beximco Pharmaceuticals Ltd.Perinase is availble in all over Bangladesh.
Mes BD drug index information on Perinase Nasal Spray is not intended for diagnosis, medical advice or treatment; neither intended to be a substitute for the exercise of professional judgment.