Pediclor Syrup
Chloral Hydrate
143.3 mg
Beacon Pharmaceuticals Ltd.
| Pack size | 100ml |
|---|---|
| Unite Price | 200.00 BDT |
Indications
Pediclor Syrup is used for:
Insomnia, Sedation, Anxiety
Adult Dose
Oral
Hypnotic, Insomnia
Adult: 0.5-1 g as a single dose 15-30 min before bedtime or 30 min prior to surgery. Max: 2 g daily.
Rarely used for this indication
Treatment duration: <2 wk.
Elderly: 250 mg 15-30 min before bedtime.
Sedation
Adult: 250 mg tid. Max: 2 g daily.
Hepatic Impairment
Contraindicated in moderate-severe hepatic impairment
Child Dose
Oral
Hypnotic, Insomnia
Child:
2-11 yr 30-50 mg/kg as a single dose 15-30 min before bedtime.
Max: 1 g daily;
>12 yr 0.5-1 g as a single dose 15-30 min before bedtime.
Max: 2 g daily.
Treatment duration: <2 wk.
Sedation for Procedures (Off-label)
50-75 mg/kg PO 30-60 min before procedure; may repeat in 30 min if necessary
Not to exceed 120 mg/kg or 1 g/dose in infants or 2 g/dose in children
Sedation/Anxiety (Off-label)
May be used prior to procedure or EEG evaluation
25-50 mg/kg/day PO divided q6-8hr; not to exceed 500 mg/dose
Renal Dose
Renal Impairment
Contraindicated in moderate-severe renal impairment
Administration
Upon discontinuation withdraw gradually over 2 weeks if patient maintained on high doses for prolong periods of time; abrupt discontinuation may result in delirium. Dilute w/ water or other liquids (e.g. fruit juice, ginger ale).
Contra Indications
Hypersensitivity/idiosyncrasy to chloral derivatives.
Severe cardiac disease, acute porphyria, gastritis, oesophagitis, gastric/duodenal ulcer; obstructive sleep apnoea in childn. Marked hepatic or renal impairment. Lactation.
Precautions
Patient w/ resp insufficiency, sleep apnoea, depression, suicidal tendency, history of drug or alcohol abuse. Childn, elderly. Pregnancy.
Potential toxic dose <6 years old: 50 mg/kg
Use with caution in porphyria
Use caution in long term care patients, elderly, and neonates
Use not recommended for >2 weeks
Abrupt discontinuation may cause withdrawal symptoms
Pregnancy-Lactation
Pregnancy Category: C
Lactation: small amount secreted into breast milk
Interactions
Enhanced sedative effect w/ opiates, barbiturates, TCAs, antipsychotics, antihistamines, and other sedatives. May cause hot flushes, sweating, and HTN w/ IV furosemide. May cause delirium w/ anticholinergics or psychotropics. May produce a transient increase in hypoprothrombinemic response to warfarin.
Side Effects
Side effects of Chloral Hydrate :
Significant: Gastric irritation (e.g. nausea, vomiting, diarrhoea), abdominal distention, flatulence, tolerance, dependence.
Nervous: Drowsiness, light-headedness, headache, paradoxical excitement, hallucination, nightmares, confusion, ataxia.
GI: Gastritis, unpleasant taste.
Genitourinary: Ketonuria, parenchymatous renal injury.
Dermatologic: Erythema multiforme, Stevens-Johnson syndrome.
Potentially Fatal: Delirium tremens.
Mode of Action
Chloral hydrate is a sedative and hypnotic w/ properties similar to paraldehyde and barbiturates. Its exact mechanism of action is unknown, however, it is believed that its CNS depressant effects are due to its active metabolite, trichloroethanol.
Note
Pediclor 143.3 mg Syrup generic name is Chloral Hydrate. Pediclor 143.3 mg Syrup is manufactured by Beacon Pharmaceuticals Ltd.Pediclor is availble in all over Bangladesh.
Mes BD drug index information on Pediclor Syrup is not intended for diagnosis, medical advice or treatment; neither intended to be a substitute for the exercise of professional judgment.