Indications
Nimodi Tablet is used for:
Subarachnoid haemorrhage, Stroke prevention
Adult Dose
Oral
Prophylaxis of neurological deficit following subarachnoid haemorrhage
Adult: 60 mg 4 hrly beginning w/in 4 days of onset of haemorrhage and continued for 21 consecutive days.
Hepatic impairment: Initially, 30 mg 4 hrly.
Child Dose
Renal Dose
Administration
Cap: Should be taken on an empty stomach. Take on an empty stomach 1 hr before or 2 hr after meals.
Tab: May be taken with or without food. Take consistently, either always w/ or always w/o meals.
Contra Indications
Use w/in 1 mth of MI or an episode of unstable angina. Concomitant use w/ potent CYP3A4 inhibitors (e.g. clarithromycin, ritonavir, ketoconazole, nefazodone).
Precautions
Patients w/ cerebral oedema or severely raised intracranial pressure. Contents of oral capsules should be given only by mouth or through a feeding tube. It must never be administered IV or by any other parenteral route. Hepatic and renal impairment. Pregnancy and lactation. Monitoring Parameters Careful monitoring of BP and pulse rate.
Lactation: unknown; avoid
Pregnancy-Lactation
Interactions
Plasma concentration and efficacy may be significantly reduced when administered w/ strong CYP3A4 inducers (e.g. rifampicin, carbamazepine, phenobarbital, phenytoin). May increase serum levels and toxicity of phenytoin. Increased plasma concentrations w/ cimetidine or sodium valproate.
Potentially Fatal: Increased risk of significant hypotension w/ concomitant potent CYP3A4 inhibitors (e.g. clarithromycin, ritonavir, ketoconazole, nefazodone).
Side Effects
Side effects of Nimodipine :
1-10%
Reduction in systemic blood pressure (1-8%), Diarrhea (2-4%), Headache (1-4%), Abdominal discomfort (2%), Rash (1-2%)
<1%
Heart failure, Arrhythmia, Anemia, ECG abnormalities, GI hemorrhage, Hepatitis, Jaundice, Thrombocytopenia, Vomiting, Thrombosis, Rebound vasospasm
Potentially Fatal: Angina/MI, symptomatic hypotension.
Mode of Action
Nimodipine inhibits inflow of Ca ions into cells by blocking Ca channels or select voltage-sensitive areas resulting in relaxation of vascular smooth muscle and myocardium during depolarisation. Nimodipine has greater action on the cerebral vessels because of its high lipophilicity.
Note
Nimodi 30mg Tablet generic name is Nimodipine. Nimodi 30mg Tablet is manufactured by Eskayef Pharmaceuticals Ltd.Nimodi is availble in all over Bangladesh.
Mes BD drug index information on Nimodi Tablet is not intended for diagnosis, medical advice or treatment; neither intended to be a substitute for the exercise of professional judgment.