Nifedipine Tablet
Nifedipine
10mg
Albion Laboratories Ltd.
| Pack size | 100's Pack |
|---|---|
| Unite Price | 0.34 BDT |
Indications
Nifedipine Tablet is used for:
Hypertension, Angina pectoris, Raynaud's syndrome, Stroke prevention
Adult Dose
Oral
Hypertension
Adult: Immediate-release: Initially, 5 mg tid. Maintenance: 10-20 mg tid.
Extended-release: Initially, 10-40 mg bid, or 20-90 mg once daily.
Angina pectoris
Adult: Immediate-release: Initially, 10 mg tid. Maintenance: 10-20 mg tid.
Extended-release: 10-40 mg bid or 30-60 mg once daily.
Raynaud's syndrome
Adult: Immediate-release: 5-20 mg tid.
Elderly: Dose reduction may be necessary.
Hepatic impairment: Dose reduction may be necessary.
Child Dose
Renal Dose
Administration
Immediate-release: May be taken with or without food. Avoid grapefruit juice.
Retard, GITS & OROS: May be taken with or without food. Avoid grapefruit juice. Swallow whole, do not chew/crush.
Contra Indications
Acute MI, cardiogenic shock, acute unstable angina, treatment of anginal attack in chronic stable angina.
Precautions
Patients w/ hypotension, poor cardiac reserve, heart failure, severe aortic stenosis, DM, underlying severe GI narrowing (extended-release tab). Avoid abrupt withdrawal as it may casue rebound angina. Hepatic impairment. Elderly. Pregnancy and lactation. Patient Counselling Discontinue if ischaemic pain follows after admin. Monitoring Parameters Monitor BP, heart rate.
Lactation: Drug is distributed into breast milk; manufacturer suggests discontinuing drug or refraining from nursing (however, American Academy of Pediatrics states that drug is safe for nursing)
Pregnancy-Lactation
Interactions
Enhanced antihypertensive effects w/ other antihypertensives, aldesleukin, and antipsychotics. Concomitant use w/ fentanyl during surgery caused severe hypotension. May modify insulin and glucose responses. Attenuation of tachycardic effect when used w/ benazerpril. Prothrombin time may be increased w/ coumarin anticoagulants. Increased serum levels w/ CYP3A4 inhibitors (e.g. azole antifungals, cimetidine, erythromycin, HIV-protease inhibitors, nefazodone, fluoxetine, quinupristin/dalfopristin).
Potentially Fatal: Decreased bioavailability and efficacy w/ strong CYP3A4 inducers (e.g. rifampicin, phenytoin, carbamazepine).
Side Effects
Side effects of Nifedipine :
>10%
Peripheral edema (10-30%), Dizziness (23-27%), Flushing (23-27%), Headache (10-23%), Heartburn (11%), Nausea (11%)
1-10%
Muscle cramps (8%), Mood change (7%), Nervousness (7%), Cough (6%), Dyspnea (6%), Palpitations (6%), Wheezing (6%), Hypotension, transient (5%), Urticaria (2%), Pruritus (2%), Constipation (<2%), Chest pain (<2%)
Frequency Not Defined
Gingival hyperplasia, Agranulocytosis, Erectile dysfunction
Mode of Action
Nifedipine prevents Ca ion from entering the slow channels of cardiac and smooth muscles during depolarisation, producing peripheral and coronary vasodilatation. It reduces afterload, peripheral resistance and BP; increases coronary blood flow and causes reflex tachycardia. It has little or no effect on cardiac conduction and rarely has negative inotropic activity.
Note
Nifedipine 10mg Tablet generic name is Nifedipine. Nifedipine 10mg Tablet is manufactured by Albion Laboratories Ltd.Nifedipine is availble in all over Bangladesh.
Mes BD drug index information on Nifedipine Tablet is not intended for diagnosis, medical advice or treatment; neither intended to be a substitute for the exercise of professional judgment.