Neobetrin Ointment
Bacitracin Zinc + Neomycin Sulphate Topical
500IU + 5mg
DBL pharmaceuticals ltd.
| Pack size | 20gm |
|---|---|
| Unite Price | 44.00 BDT |
Indications
Neobetrin Ointment is used for:
Bacterial skin infections
Adult Dose
Adult: Topical: Cream: Apply 3 times/day.
Powder: Apply 2-4 times/day.
Child Dose
Topical: Cream: Apply 3 times/day.
Powder: Apply 2-4 times/day.
Renal Dose
Administration
Contra Indications
Hypersensitivity to aminoglycosides. Pre-existing nerve deafness. Neonates and infants <2 yr.
Precautions
Avoid application in large quantities and prolonged use. Pregnancy and lactation. Liver and renal impairment.
Pregnancy-Lactation
Interactions
Bacitracin Zinc: Increased risk of nephrotoxicity when used with other nephrotoxic drugs. May enhance the action of neuromuscular-blocking agents.
Neomycin Sulphate: Additive nephrotoxic and neurotoxic effect w/ other aminoglycosides (e.g. paromomycin), bacitracin, cisplatin, vancomycin, amphotericin B, polymyxin B, colistin and viomycin. Enhanced toxicity w/ potent diuretics (e.g. ethacrynic acid, furosemide). May impair the absorption of other drugs (e.g. phenoxymethylpenicillin, digoxin, methotrexate and some vit). May reduce the efficacy of OCs. May enhance the effect of acarbose. May enhance the effect of non-depolarising muscle relaxants. May antagonise the parasympathomimetic effect of neostigmine and pyridostigmine. May increase the risk of hypocalcaemia in patients receiving bisphosphonates. May alter INR when given w/ anticoagulants. May inactivate oral typhoid vaccine.
Side Effects
Side effects of Bacitracin Zinc + Neomycin Sulphate Topical :
>10%
Allergic contact dermatitis (60%)
Mode of Action
Neomycin, an aminoglyoside with antimicrobial spectrum similar to gentamicin, binds to the 30S subunits of the bacterial ribosome, inhibiting protein synthesis and thereby disrupting DNA synthesis. It is active against many gram-negative aerobes and against some strains of staphylococci. Bacitracin, on the other hand, inhibits bacterial cell wall synthesis and is active against many gram-positive bacteria (e.g. staphylococci, streptococci, corynebacteria and clostridia) and some gram-negative species (e.g. Neisseria and Haemophilus influenzae). They are often found in combinations in topical preparations as broad spectrum antibacterial agents.
Note
Neobetrin 500IU + 5mg Ointment generic name is Bacitracin Zinc + Neomycin Sulphate Topical. Neobetrin 500IU + 5mg Ointment is manufactured by DBL pharmaceuticals ltd.Neobetrin is availble in all over Bangladesh.
Mes BD drug index information on Neobetrin Ointment is not intended for diagnosis, medical advice or treatment; neither intended to be a substitute for the exercise of professional judgment.