Nabuton Tablet
Nabumetone
750 mg
Navana Pharmaceuticals Ltd.
| Pack size | 24's pack |
|---|---|
| Unite Price | 22.00 BDT |
Indications
Nabuton Tablet is used for:
Relieve of, Acute & Chronic Pain and inflammation, associated with Osteoarthritis, Rheumatoid Arthritis and Musculoskeletal & joint disorders,
Adult Dose
Oral
Adult
Osteoarthritis
1g PO once daily initially; maintenance: 1-2 g/day PO in single daily dose or divided q12hr; not to exceed 2 g/day
Rheumatoid Arthritis
1 g PO once daily initially; maintenance: 1-2 g/day PO in single daily dose or divided q12hr; not to exceed 2 g/day
Elderly: 500 mg daily may be adequate in certain patients. Max: 1 g daily.
Child Dose
Not recommended
Renal Dose
Renal impairment:
CrCl (ml/min) Dosage Recommendation
30-49 Max initial dose: 750 mg once daily. Increase if needed to a max dose of 1.5 g daily.
<30 Max initial dose: 500 mg once daily. Increase if needed to a max dose of 1 g daily.
Administration
Should taken with food.
Contra Indications
Absolute: Aspirin allergy, severe renal impairment; perioperative pain in setting of coronary artery bypass graft (CABG) surgery
Relative: Duodenal/gastric/peptic ulcer, stomatitis, systemic lupus erythematosus, ulcerative colitis, late pregnancy (may cause premature closure of ductus arteriosus)
Precautions
Pre-existing CV risk factors or disease; fluid retention, CHF, hypertension. History of GI disease (bleeding or ulcers). Elderly or debilitated patients. Other forms of asthma. Hepatic impairment; closely monitor patients with any abnormal LFT. Renal impairment; rehydrate patient prior to therapy and closely monitor renal function. Withhold for at least 4-6 half-lives prior to surgical or dental procedures.
Pregnancy-Lactation
Pregnancy category: C; D if used for prolonged periods or near term (premature closure of ductus arteriosus)
Lactation: Unknown whether drug is excreted in breast milk; effect on infant unknown; do not give to nursing mothers
Interactions
Antihypertensive effects of hypotensive agents may be reduced. May increase ciclosporin levels. Increased risk of seizures with fluoroquinolones. May reduce efficacy of diuretics. May diminish the cardioprotective effect of acetylated salicylates. Alcohol may enhance gastric mucosal irritation.
Potentially Fatal: Increased risk of bleeding with anticoagulants (e.g. warfarin, heparin, LMWHs) and antiplatelet agents (e.g. ticlopidine, clopidogrel, aspirin, abciximab, dipyridamole, eptifibatide, tirofiban).
Increased risk of GI ulceration with corticosteroids. Severe bone marrow suppression, aplastic anaemia and GI toxicity may occur with methotrexate.
Side Effects
Side effects of Nabumetone :
>10%
Diarrhea (14%), Dyspepsia (13%), Abdominal pain (12%)
1-10%
Constipation (3-9%), Dizziness (3-9%), Edema (3-9%), Flatulence (3-9%), Headache (3-9%), Nausea (3-9%), Positive stool guaiac (3-9%), Pruritus (3-9%), Rash (3-9%), Tinnitus (3-9%), Dry mouth (1-3%), Fatigue (1-3%), Gastritis (1-3%), Increased sweating (1-3%), Insomnia (1-3%), Nervousness (1-3%), Somnolence (1-3%), Stomatitis (1-3%), Vomiting (1-3%)
Mode of Action
Inhibits synthesis of prostaglandins in body tissues by inhibiting at least 2 cyclooxygenase (COX) isoenzymes, COX-1 and COX-2
May inhibit chemotaxis, alter lymphocyte activity, decrease proinflammatory cytokine activity, and inhibit neutrophil aggregation; these effects may contribute to anti-inflammatory activity
Note
Nabuton 750 mg Tablet generic name is Nabumetone. Nabuton 750 mg Tablet is manufactured by Navana Pharmaceuticals Ltd.Nabuton is availble in all over Bangladesh.
Mes BD drug index information on Nabuton Tablet is not intended for diagnosis, medical advice or treatment; neither intended to be a substitute for the exercise of professional judgment.