Indications
Myleran Tablet is used for:
Chronic myeloid leukaemia, Bone marrow transplantation, Polycythemia vera, Essential thrombocythemia,
Adult Dose
Oral
Palliative treatment of chronic myeloid leukemia
Adult: 60 mcg/kg daily. Maintenance: 0.5-2 mg daily. Max: 4 mg daily.
Polycythemia vera
Adult: 4-6 mg daily continued for 4-6 wk with blood counts monitoring.
Essential thrombocythemia
Adult: 2-4 mg daily.
Conditioning regimens for bone marrow transplantation
Adult: 3.5-4 mg/kg daily in divided doses for 4 days up to a total dose of 14-16 mg/kg. Usually used with cyclophosphamide for ablation of recipient's bone marrow.
Child Dose
Renal Dose
Administration
May be taken with or without food. Take w/ chilled liqd, ensure adequate fluid intake.
Contra Indications
Pregnancy and lactation. Hypersensitivity.
Precautions
Prior treatment with other myelosuppressive drugs, patients predisposed to seizures. May cause secondary malignancies (tumors, acute leukaemias, ovarian failure). Previous irradiation/therapy. Monitor blood counts carefully during therapy. Discontinue if lung toxicity develops.
Pregnancy-Lactation
Interactions
Decreased clearance when used with cyclophosphamide and itraconazole. Increased clearance by phenytoin. May reduce response to vaccines, possibility of generalized infections with live vaccines. Combination with thioguanine results in oesophageal varices and abdominal liver function tests.
Potentially Fatal: Cytotoxic agents may increase risk of pulmonary toxicity.
Side Effects
Side effects of Busulphan :
GI symptoms, anorexia, wt loss, weakness, hyperpigmentation, amenorrhoea, cataracts, cough or hoarseness, impaired fertility and gonadal function, dry skin, liver damage, gynaecomastia.
Potentially Fatal: Bone marrow depression manifesting as thrombocytopaenia, leucopaenia, anaemia. Interstitial pulmonary fibrosis (known as "busulfan lung" on prolonged treatment).
Mode of Action
Busulfan reacts with N-7 position of guanosine and interferes with DNA replication and RNA transcription by alkylating and cross-linking the DNA strands.
Note
Myleran 2mg Tablet generic name is Busulphan. Myleran 2mg Tablet is manufactured by Excella, GermanyMyleran is availble in all over Bangladesh.
Mes BD drug index information on Myleran Tablet is not intended for diagnosis, medical advice or treatment; neither intended to be a substitute for the exercise of professional judgment.