Indications
Miltefos 50 Capsule is used for:
Visceral leishmaniasis, Mycosis fungoides, Skin metastases of breast cancer
Adult Dose
Adult : PO Visceral Leishmaniasis 100-150 mg/day for 28 days.
Child Dose
Child: PO 2.5 mg/kg/day bid
>12 y: 30–44 kg: 100 mg/day bid
>45 kg: 150 mg/day tid
Renal Dose
Administration
Contra Indications
Pregnancy, lactation, concurrent radiation therapy.
Precautions
Metastases grown over breast implants. Increased serum creatinine, ALT, AST, bilirubin reported; monitor. Thrombocytopenia reported; monitor platelets
Stevens-Johnson syndrome reported; discontinue if an exfoliative or bullous rash occurs
Lactation: Unknown if distributed in human breast milk; avoid breastfeeding during therapy and for 5 months following therapy
Pregnancy-Lactation
Pregnancy Category: D (see Black Box Warnings); Human pregnancy data are not available; however, embryofetal toxicity, including death and teratogenicity, was observed in embryo-fetal studies in rats and rabbits
Clinical considerations: During pregnancy, visceral leishmaniasis may be life-threatening for the mother and may result in adverse fetal outcomes, including spontaneous abortion, congenital disease due to vertical transmission, small for gestational age newborn, and severe anemia
Lactation: Unknown if distributed in human breast milk; avoid breastfeeding during therapy and for 5 months following therapy
Interactions
Side Effects
Side effects of Miltefosine :
>10%
Visceral leishmaniasis
Increased transaminases, <3 x ULN (94%), Decreased platelets <150, 000 (62%), Vomiting (37.8%), Decreased appetite (23.1%), Diarrhea (20.4%)
1-10%
Visceral leishmaniasis
Increased serum creatinine, >1.5 x baseline (10%), Asthenia (6.3%), Increased transaminases, 3-5 x ULN (6%), Decreased platelets <50, 000 (2.4%)
Mode of Action
Miltefosine is a phospholipid derivative thought to work by disrupting cell-membrane function.
Note
Miltefos 50 50mg Capsule generic name is Miltefosine. Miltefos 50 50mg Capsule is manufactured by Popular Pharmaceuticals Ltd.Miltefos 50 is availble in all over Bangladesh.
Mes BD drug index information on Miltefos 50 Capsule is not intended for diagnosis, medical advice or treatment; neither intended to be a substitute for the exercise of professional judgment.