Merozolyn Tablet
Metolazone
500mcg
Unimed & Unihealth Manufacturers Ltd.
| Pack size | |
|---|---|
| Unite Price | 5.00 BDT |
Indications
Merozolyn Tablet is used for:
Oedema, Hypertension
Adult Dose
Oral
Hypertension
Adult: Initially, 1.25 mg daily, adjusted after 3-4 wk according to response. Usual dose: 2.5-5 mg daily, either alone or with other antihypertensives.
Maintenance dose: 5 mg on alternate days.
Formulations with enhanced bioavailability: 0.5-1 mg daily.
Oedema
Adult: 5-10 mg daily, increased if necessary to 20 mg daily. Max: 80 mg in 24 hr.
Elderly: Initially, 2.5 mg/day or every other day.
Child Dose
Oedema
0.2-0.4 mg/kg/day PO in single daily dose or divided q12hr
Renal Dose
Renal impairment: Not necessary to supplement dose in hemodialysis or peritoneal dialysis
Administration
Should be taken with food. Take after breakfast.
Contra Indications
Anuria; hepatic coma or pre-coma. Pregnancy.
Precautions
Pre-diabetes or DM; gout; SLE; hepatic and renal impairment; hypercholesterolaemia. Correct electrolyte disturbances prior to therapy. Risk of cross-sensitivity with sulfonamides, sulfonylureas, carbonic anhydrase inhibitors, thiazides and loop diuretics.
Lactation: Not recommended
Pregnancy-Lactation
Pregnancy
Drug appears in cord blood and crosses placenta; hypokalemia, hypoglycemia, jaundice, thrombocytopenia, and hyponatremia reported in fetus or newborn following maternal use of thiazide diuretics
Lactation
Drug excreted in breast milk; decision on whether to discontinue nursing or discontinue drug should be based on importance of treatment to mother
Interactions
Hypotensive and nephrotoxic effects of ACE inhibitors may be enhanced. Absorption may be reduced with bile acid sequestrants. Hyperglycaemic effect may be enhanced with diazoxide. May increase serum concentration and QTc-prolonging effect of dofetilide. May reduce lithium excretion. Hypotensive effect may be increased with alcohol.
Potentially Fatal: Increased risk of nephrotoxicity with ciclosporin. Severe electrolyte disturbances may occur with furosemide.
Side Effects
Side effects of Metolazone :
Chest pain, palpitation, necrotising angiitis, orthostatic hypotension, syncope, venous thrombosis, vertigo, volume depletion; depression, dizziness, chills, drowsiness, fatigue, restlessness, headache, lightheadedness; petechiae, photosensitivity, hypersensitivity reactions; gout attacks, electrolyte disturbances; abdominal bloating, diarrhoea, abdominal pain, anorexia, constipation, epigastric distress, nausea, xerostomia, pancreatitis, vomiting; impotence; aplastic anaemia, thrombocytopenia, haemoconcentration, leukopenia; cholestatic jaundice, hepatitis; joint pain, muscle cramps, weakness, neuropathy, paraesthesia; blurred vision; increased BUN, glucosuria.
Potentially Fatal: Stevens-Johnson syndrome, toxic epidermal necrolysis.
Mode of Action
Metolazone is a thiazide-like diuretic. It inhibits reabsorption of sodium in the distal tubules resulting in increased excretion of sodium and water, as well as potassium and hydrogen ions.
Note
Merozolyn 500mcg Tablet generic name is Metolazone. Merozolyn 500mcg Tablet is manufactured by Unimed & Unihealth Manufacturers Ltd.Merozolyn is availble in all over Bangladesh.
Mes BD drug index information on Merozolyn Tablet is not intended for diagnosis, medical advice or treatment; neither intended to be a substitute for the exercise of professional judgment.