Maxpro HP Capsule
Esomeprazole + Amoxicillin + Clarithromycin Kit
Renata Limited
| Pack size | 14's |
|---|---|
| Unite Price | 55.00 BDT |
Indications
Maxpro HP Capsule is used for:
Eradication of H. pylori, in active chronic gastric,duodenal and gastric ulcers.
Adult Dose
Oral
Each strip contain one Esomeprazole USP 20mg capsule, two Amoxicillin BP 500mg tablets and one Clarithromycin USP 500mg tablet
Each strip twice daily for 7-14 days
Child Dose
Renal Dose
Administration
Contra Indications
Contraindicated in patients with known hypersensitivity to any of its compo-nent.
Precautions
Serious and occasionally fatal hypersensitivity reactions have been reported in patients on Amoxicillin therapy. These reactions are more apt to occur in indivduals with a history of penicillin hypersensitivity. Clarithromycin should not used in pregnant women except in clinical circumstances where no alternative is appropriate.
Pregnancy-Lactation
Interactions
Esomeprazole is metabolized through the cytochrome P450 system, specially through the CYP3A isozymes. Studies have shown that Esomeprazole does not have clinically significant interactions with other drugs metabolized by the cytochrome P450 system, such as warfarin, antipyrine, indomethacin, ibuprofen, phenytoin, propranolol, prednisolone, diazepam, clarithromycin or terfenadine in healthy subject.
Clarithromycin use in patients who are receiving theophylline may be associated with an increase of serum theophylline concentrations.
There have been reports of interactions of clarithromycin with carbamazepine, cyclosporine, tactrolimus, hexobarbital, phenytoin, alfetanil, disopyramide, lovastatin, bromocriptine, valproate, terfenadine, cisapride, pimozide & astemizole.
Side Effects
Side effects of Esomeprazole + Amoxicillin + Clarithromycin Kit :
Common adverse reactions included diarrhoea and nausea.
>10%
Clarithromycin
GI effects, general (13%)
1-10%
Clarithromycin
Headache (6%), Rash (children 3%), Abdominal pain (adults 2%, children 3%), Abnormal taste (adults 3-7%), Diarrhea (3-6%), Dyspepsia (2%), Heartburn (adults 2%), GI intolerance (oral-dose related), Nausea (adults 3-6%), Vomiting (adults 1%; children 6%), Decreased WBC, elevated BUN (4%), elevated PT (1%)
Esomeprazole
>10%
Headache (2-11%)
1-10%
Flatulence (10%), Indigestion (6%), Nausea (6%), Abdominal pain (1-6%), Diarrhea (2-4%), Xerostomia (3-4%), Dizziness (2-3%), Constipation (2-3%), Somnolence (1-2%), Pruritus (1%)
Frequency Not Defined
Amoxicillin
Headache, Rash, Diarrhea, nausea, vomiting, Anemia, AST/ALT elevation, Acute exanthematous pustulosis, Exfoliative dermatitis
Seizure, Insomnia, Hemorrhagic colitis, Toxic epidermal necrolysis, Urticaria, Stevens-Johnson syndrome, Anaphylaxis, Candidiasis (mucocutaneous), pseudomembranous colitis, serum sickness
Mode of Action
Amoxicillin: Inhibits bacterial cell wall synthesis by binding to one or more penicillin binding proteins that in turn inhibit the final transpeptidation step of peptoglycan synthesis in cell wall biosynthesis.
Clarithromycin: Inhibits protein synthesis by binding to 50S ribosomal subunit causing antibacterial activity.
Esomeprazole is a PPI that suppresses gastric acid secretion by inhibiting H+/K+ ATPase in the gastric parietal cell.
Note
Maxpro HP Capsule generic name is Esomeprazole + Amoxicillin + Clarithromycin Kit. Maxpro HP Capsule is manufactured by Renata LimitedMaxpro HP is availble in all over Bangladesh.
Mes BD drug index information on Maxpro HP Capsule is not intended for diagnosis, medical advice or treatment; neither intended to be a substitute for the exercise of professional judgment.