Indications
Maxbuten Syrup is used for:
Respiratory tract infections, Urinary tract infections
Adult Dose
Oral
Respiratory tract infections, Urinary tract infections
Adult: 400 mg once daily for 10 days.
Child Dose
Child:
<6 months: Safety and efficacy not established
6-12 years old or <45 kg: 9 mg/kg PO qDay; 400 mg/day PO for 10 days maximum
>12 years old or >45 kg: As in adults
Renal Dose
Renal impairment:
CrCl (ml/min)
30-49 200 mg once daily.
5-29 100 mg once daily.
Administration
Susp: Should be taken on an empty stomach. Take 2 hr before or 1 hr after meals.
Cap: May be taken with or without food.
Contra Indications
Hypersensitivity to cephalosporins.
Precautions
Hypersensitivity to penicillins; renal impairment; Porphyria. Monitor renal and haematologic status.
Lactation: excretion in milk unknown; use with caution
Pregnancy-Lactation
Pregnancy Category: B
Lactation: excretion in milk unknown; use with caution
Interactions
Enhanced nephrotoxicity of aminoglycosides. Increased serum concentration w/ probenecid. Decreased serum concentration w/ zinc salts.
Side Effects
Side effects of Ceftibuten :
1-10%
Increased BUN (4%), Nausea (4%), Diarrhea (3%), Headache (3%), Increased eosinophils (3%), Decreased hemoglobin (2%), Dyspepsia (2%), Thrombocytosis (2%), Abdominal pain (1%), Dizziness (1%), Increased ALT (1%), Increased bilirubin (1%), Vomiting (1%)
<1%
Anorexia, Candidiasis, Constipation, Dysuria, Agitation, Fatigue, Insomnia, Irritability, Paresthesia, Rigors, Diaper rash, Urticaria, Dry mouth, Dyspnea, Nasal congestion, Increased transaminases, Increased creatinine, Leukopenia
Potentially Fatal: Pseudomembranous colitis.
Mode of Action
Ceftibuten inhibits bacterial cell wall synthesis. It is stable to hydrolysis by many beta-lactamases and has greater activity than 1st or 2nd generation cephalosporins against gm-ve bacteria. It is less active in vitro than cefexime against S. pneumoniae.
Note
Maxbuten 90 mg/5 ml Syrup generic name is Ceftibuten. Maxbuten 90 mg/5 ml Syrup is manufactured by Synovia Pharma PLC.Maxbuten is availble in all over Bangladesh.
Mes BD drug index information on Maxbuten Syrup is not intended for diagnosis, medical advice or treatment; neither intended to be a substitute for the exercise of professional judgment.