Lotrel T Eye Drops
Loteprednol Etabonate 0.5% + Tobramycin 0.3% Eye prep
(0.5 gm + 0.3 gm)/100 ml
Eskayef Pharmaceuticals Ltd.
| Pack size | |
|---|---|
| Unite Price | 200.00 BDT |
Indications
Lotrel T Eye Drops is used for:
Keratitis, Allergic conjunctivitis, Iritis, Ocular inflammation, Bacterial ocular infection, Cyclitis
Adult Dose
Ocular Inflammation
Indicated for steroid-responsive ocular inflammations with risk of superficial bacterial infections
Adult: Instill 1 or 2 drops of into the conjunctival sac of the affected eye(s) every 4 to 6 hours.; may use as frequently as q1-2hr during first 24-48 hr
Decrease frequency of administration as signs and symptoms improve
Child Dose
Safety & efficacy not been established.
Renal Dose
Administration
Contra Indications
Hypersensitivity to any component of the formulation or to other corticosteroids
Viral, mycobacterial & fungal eye infections
Precautions
History of herpes simplex infections
May exacerbate infections by nonsusceptible organisms
Monitor IOP if used >10 d
Bacterial keratitis reported from inadvertent contamination of multiple dose ophthalmic solution
Immunosuppression resulting from prolonged use of steroid use may result in secondary bacterial and fungal infections; steroids may also mask symptoms of infections and enhance existing ocular infections
Ocular hypertension and/or glaucoma reported with prolonged corticosteroid use
Discontinue use if sensitivity reaction to tobramycin develops
Corticosteroid use following cataract surgery may delay healing
Lactation: Excretion in milk unknown; use caution
Pregnancy-Lactation
Pregnancy Category: C
Lactation: Excretion in milk unknown; use caution
Interactions
Enhanced neurotoxic and nephrotoxic effects w/ other aminoglycosides (e.g. amikacin, streptomycin), cefaloridine, viomycin, polymyxin B, colistin, cisplatin and vancomycin. Enhanced toxicity w/ potent diuretics (e.g. ethacrynic acid, furosemide). Prolonged secondary apnoea may occur when given to anaesthetised patients receiving neuromuscular blocking agents (e.g. succinylcholine, tubocurarine, decamethonium). Increased risk of nephrotoxicity w/ ciclosporin and other antibacterials (e.g. cephalosporins). Antagonistic effect w/ neostigmine and pyridostigmine. May potentiate the effect of warfarin and phenindione.
Side Effects
Side effects of Loteprednol Etabonate 0.5% + Tobramycin 0.3% Eye prep :
Prolonged use may increase: IOP, which may be associated with possible development of glaucoma and infrequent optic nerve damage; posterior sub-capsular cataract formation and perforation of the globe where there is thinning of the cornea or sclera.
The most frequent adverse reactions to topical tobramycin are hypersensitivity and localized ocular toxicity, including lid itching and swelling and conjunctival erythema.
Mode of Action
Loteprednol is a synthetic nonfluorinated glucocorticoid. It stimulates the production of lipicortins, proteins that modulate the activity of prostaglandins and leukotrienes.
Tobramycin acts by binding to 30S ribosomal subunits thus interfering with bacterial protein synthesis. It is active against many aerobic gram-negative bacteria and some aerobic gram-positive bacteria but inactive against Chlamydia, fungi, viruses, and most anaerobic bacteria.
Note
Lotrel T (0.5 gm + 0.3 gm)/100 ml Eye Drops generic name is Loteprednol Etabonate 0.5% + Tobramycin 0.3% Eye prep. Lotrel T (0.5 gm + 0.3 gm)/100 ml Eye Drops is manufactured by Eskayef Pharmaceuticals Ltd.Lotrel T is availble in all over Bangladesh.
Mes BD drug index information on Lotrel T Eye Drops is not intended for diagnosis, medical advice or treatment; neither intended to be a substitute for the exercise of professional judgment.