Lotrel G Suspension
Loteprednol + Gatifloxacin eye prep
0.5%+0.3%
Eskayef Pharmaceuticals Ltd.
| Pack size | 5 ml |
|---|---|
| Unite Price | 250.00 BDT |
Indications
Lotrel G Suspension is used for:
Post-operative inflammatory conditions of the eye
Adult Dose
Ophthalmic
Adult
Apply one or two drops of this suspension into the conjunctival sac of the affected eye(s) every four to six hours.
During the initial 24 to 48 hours, the dosing may be increased, to every one to two hours.
Frequency should be decreased gradually as warranted by improvement in clinical signs. Care should be taken not to discontinue therapy prematurely.
Child Dose
Renal Dose
Administration
Contra Indications
Loteprednol and Gatifloxacin as with other ophthalmic corticosteroids, is contraindicated in most viral diseases of the cornea and conjunctiva including epithelial herpes simpiex and also in mycobacterial infection of the eye and fungal diseases of ocular structures. It is also contraindicated in individuals with known or suspected hypersensitivity to any of the ingredients of this preparation and to other corticosteroids. It is also contraindicated in patients with a history of hypersensitivity to other quinlones, acetylsalicylic acid and other nonsteroidal anti-inflammatory medicines.
Precautions
General: Patients should be advised not to wear contact lenses if they have signs and symptoms of bacterial conjunctivitis.
Fungal infections of the cornea are particularly prone to develop coincidentally with long term local steroid application.
Patients with bleeding tendencies: This fixed dose combination should be used with care in patients with known bleeding tendencies, or in patients who are receiving other medications which may prolong bleeding time.
Ability to drive: As this fixed dose combination may cause transient blurring on instillation, the use of hazardous machinery or driving is not recommended unless vision is clear.
Pregnancy-Lactation
Interactions
Side Effects
Side effects of Loteprednol + Gatifloxacin eye prep :
The adverse events reported with the fixed dose combination were irritation, pain, redness, photophobia, stinging, itching, discharge & blurred vision. Redness was the most commonly observed adverse event occurring in 6% of patients. Itching, discharge, photophobia & blurred vision were seen in less than 2% cases.
Mode of Action
Loteprednol etabonate is an ester based corticosteroid which controls the formation of prostaglandin and leukotrienes and reduces ocular inflammation. The antibacterial action of Gatifloxacin results from inhibition of DNA gyrase and topoisomerase IV. DNA gyrase is an essential enzyme that is involved in the replication, transcription and repair of bacterial DNA. Topoisomerase IV is an enzyme known to play a key role in the partitioning of the chromosomal DNA during bacterial cell division.
Note
Lotrel G 0.5%+0.3% Suspension generic name is Loteprednol + Gatifloxacin eye prep. Lotrel G 0.5%+0.3% Suspension is manufactured by Eskayef Pharmaceuticals Ltd.Lotrel G is availble in all over Bangladesh.
Mes BD drug index information on Lotrel G Suspension is not intended for diagnosis, medical advice or treatment; neither intended to be a substitute for the exercise of professional judgment.