Indications
Lomir Tablet is used for:
Hypertension
Adult Dose
Oral
Hypertension
Adult: Initially, 2.5 mg bid, increase if necessary after 3-4 wk to 5 mg bid, or 10 mg bid as required.
Elderly: Initially, 1.25 mg bid. Maintenance: 2.5 or 5 mg once daily.
Hepatic impairment: Initially 1.25 mg bid. Maintenance: 2.5 or 5 mg once daily.
Child Dose
Renal Dose
Administration
May be taken with or without food.
Contra Indications
Cardiogenic shock; recent MI or acute unstable angina; severe aortic stenosis; lactation; porphyria.
Precautions
Hypotension, poor cardiac reserve, heart failure. Pregnancy.
Lactation: not known if excreted into breast milk
Pregnancy-Lactation
Pregnancy Category: C
Lactation: not known if excreted into breast milk
Interactions
Concurrent admin w/ enzyme-inducing drugs (e.g. rifampicin, phenobarbital, carbamazepine) reduced plasma concentrations of isradipine. Increased bioavailability w/ cimetidine. May increase serum levels w/ CYP3A4 inhibitors (e.g. macrolides, HIV protease inhibitors, azole antifungals, delavirdine).
Side Effects
Side effects of Isradipine :
>10%
Headache (2-22%)
1-10%
Edema (1-9%), Dizziness (2-8%), Palpitation (1-5%), Flushing (1-5%), Tachycardia (1-3%), Chest pain (2-3%), Rash (2%), Nausea (1-5%), Vomiting (<1%), Diarrhea (≤ 3%), Weakness (<1%), Dyspnea (1-3%), Urinary frequency (1-3%)
<1%
Drug-induced gingival hyperplasia, Angioedema, Drowsiness, Hyperhidrosis, Leg pain, Nasal congestion.Drug fever, Dysuria.Impotence, Pruritus, Urticaria, Weight gain, Myocardial infarction
Mode of Action
Isradipine is a dihydropyridine Ca channel blocker. It prevents Ca ions from entering the slow channels or select voltage-sensitive areas of vascular smooth muscle and myocardium during depolarisation, producing a relaxation of coronary vascular smooth muscle and coronary vasodilation.
Note
Lomir 2.5mg Tablet generic name is Isradipine. Lomir 2.5mg Tablet is manufactured by Novartis (Bangladesh) Ltd.Lomir is availble in all over Bangladesh.
Mes BD drug index information on Lomir Tablet is not intended for diagnosis, medical advice or treatment; neither intended to be a substitute for the exercise of professional judgment.