Indications
Licef Suspension is used for:
Pharyngitis, Susceptible infections, Sore throat, Tonsillitis, Urinary tract infection, Reproductive tract infection, Skin infections
Adult Dose
Oral
Tonsillitis; Skin and skin structure infections; Streptococcal pharyngitis; Urinary tract infections
Adult: 1-2 g daily as a single or in 2 divided doses.
Hepatic impairment: No dosage adjustment needed.
Child Dose
Oral
Tonsillitis; Skin and skin structure infections; Streptococcal pharyngitis; Urinary tract infections
Child: >6 yr <40 kg: 30-50 mg/kg daily as a single or in 2 divided doses, up to 100 mg/kg daily.
Renal Dose
Renal impairment:
CrCl (ml/min)
26-50 0.5-1 g bid.
11-25 0.5-1 g once daily.
<10 0.5-1 g every 36 hr.
Administration
May be taken with or without food. May be taken w/ meals to reduce GI discomfort.
Contra Indications
Hypersensitivity to cephalosporins.
Precautions
Impaired renal function; pregnancy and lactation.
Lactation: enters breast milk; use with caution
Pregnancy-Lactation
Pregnancy Category: B
Lactation: enters breast milk; use with caution
Interactions
Concomitant use w/ bacteriostatic antibiotics (e.g. tetracycline, erythromycin, sulfonamides, chloramphenicol) may cause antagonistic effect. May potentiate nephrotoxic effects of aminoglycoside antibiotics, polymyxin B, colistin or high-dose loop diuretics. May enhance the anticoagulant effect of vit K antagonists. May diminish the therapeutic effect of BCG, typhoid vaccine and Na picosulfate. May attenuate the effect of oral contraceptives. Increased serum concentration w/ probenecid. Reduced bioavailability w/ colestyramine.
Side Effects
Side effects of Cefadroxil :
1-10%
Diarrhea
<1%
Abdominal pain, Dyspepsia, Nausea, Vomiting, Rash, Urticaria, Pseudomembranous colitis, Stevens-Johnson syndrome, Anaphylaxis, Transaminases increased, Neutropenia
Potentially Fatal: Anaphylactic reaction; pseudomembranous colitis.
Mode of Action
Cefadroxil binds to one or more of the penicillin-binding proteins (PBPs) which inhibits the final transpeptidation step of peptidoglycan synthesis in bacterial cell wall, thus inhibiting biosynthesis and arresting cell wall assembly resulting in bacterial cell death. Cefadroxil is not active against Proteus, Pseudomonas, Enterobacter, Morganella, Serratia and Listeria monocytogenes.
Note
Licef 125 mg/5 ml Suspension generic name is Cefadroxil. Licef 125 mg/5 ml Suspension is manufactured by Asiatic Laboratories Ltd.Licef is availble in all over Bangladesh.
Mes BD drug index information on Licef Suspension is not intended for diagnosis, medical advice or treatment; neither intended to be a substitute for the exercise of professional judgment.
Some other brands of Cefadroxil :
Capsule
Adocil
500mg
Kemiko Pharmaceuticals Ltd.
Powder for Suspension
Arocef
125mg/5ml
Eskayef Pharmaceuticals Ltd.
Capsule
Arocef
500mg
Eskayef Pharmaceuticals Ltd.
Paediatric Drops
Cefador
125mg/1.2ml
Somatec Pharmaceuticals Ltd.
Powder for Suspension
Cefador
125mg/5ml
Somatec Pharmaceuticals Ltd.