Lapen 6 Lac Injection
Benzathine Penicillin
6 Lac Unit/vial
Jayson Pharmaceuticals Ltd.
| Pack size | 5 combos Pack |
|---|---|
| Unite Price | 14.60 BDT |
Indications
Lapen 6 Lac Injection is used for:
Acute otitis media, Group A Strep. infections, Rheumatic fever, Syphilis, Neurosyphilis, Streptococcal impetigo, Anthrax, Diphtheria, Uncomplicated pneumococcal pneumonia, Streptococcal pharyngitis
Adult Dose
Adult: IM: 0.3 to 1.2 million units up to 2.4 million units as a single dose repeated every five to seven days.
Specific dosage schedule:
Treatment of group-A beta-haemolytic streptococcal infections:
A single intramuscular dose of 600,000 units.
Prevention of rheumatic fever: Monthly injection of a single dose of 1.2 million units is the most effective regimen for preventing further attacks of rheumatic fever.
Treatment of acute otitis media: A single injection of 600,000 units.
Treatment of syphilis:
Early syphilis- 2.4 million units as a single dose.
Late syphilis- 2.4 million units weekly for three successive weeks.
Neurosyphilis- Benzylpenicillin, intravenously, 2 to 4 million units every 4 hours for 10 days, followed by benzathine penicillin intramuscularly, 2.4 million units weekly for three successive weeks.
Congenital syphilis: Asymptomatic infants with normal cerebrospinal fluid, intramuscularly 50,000 units per kg in a single dose.
Primary and secondary syphilis have been treated with single injections of 2.4 million units of long acting benzathine penicillin weekly for 2 to 4 weeks with satisfactory results.
Child Dose
Child: IM 50,000 U/kg for newborns and infants,
Child: IM 50,000 U/kg for newborns and infants,
children <60 lb: 300,000–600,000 U,
children >60 lb: 900,000 U
1 dose for treatment
Renal Dose
Administration
Contra Indications
Hypersensitivity to penicillins or cephalosporins. IM inj (ischaemic reactions may occur).
Precautions
Very high doses in poor renal function (risk of neurotoxicity) or heart failure. Avoid contact, skin sensitization may occur. Monitor serum potassium concentration, renal and haematological status. Spirochete infections particularly syphilis; suprainfection with penicillin-resistant organisms with prolonged use; avoid intrathecal route.
Lactation: Excreted into breast milk, caution advised
Pregnancy-Lactation
Pregnancy Category: B
Lactation: Excreted into breast milk, caution advised
Interactions
Probenecid prolongs T1/2 of benzathine benzylpenicillin. Bacteriostatic drugs e.g. chloramphenicol, tetracyclines; other antibacterials; anticoagulants.
Side Effects
Side effects of Benzathine Penicillin :
Hypersensitivity reactions including uticaria; fever; joint pains; rashes; angioedema; serum sickness-like reactions; haemolytic anaemia; interstitial nephritis; neutropenia; thrombocytopenia; CNS toxicity including convulsions; diarrhoea; antibiotic-associated colitis.
Potentially Fatal: Anaphylaxis
Mode of Action
Benzathine benzylpenicillin has the same antimicrobial action as benzylpenicillin which exerts its bactericidal action on growing and dividing bacteria by inhibiting bacterial cell wall synthesis. IM admin results in a prolonged effect, but because of its relatively low blood concentrations, its use should be restricted to microorganisms that are highly susceptible to it.
Note
Lapen 6 Lac 6 Lac Unit/vial Injection generic name is Benzathine Penicillin. Lapen 6 Lac 6 Lac Unit/vial Injection is manufactured by Jayson Pharmaceuticals Ltd.Lapen 6 Lac is availble in all over Bangladesh.
Mes BD drug index information on Lapen 6 Lac Injection is not intended for diagnosis, medical advice or treatment; neither intended to be a substitute for the exercise of professional judgment.
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