Kof-free Syrup

Guaiphenesin + Diphenhydramine + Levomenthol

280 mg + 2000 mg + 22 mg/

Benham Pharmaceuticals Ltd.

Pack size	100 ml bot
Unite Price	80.00 BDT

Indications

Kof-free Syrup is used for: Relief of cough with associated congestive symptoms

Adult Dose

Adults: Syrup 2 tsf 4 times a day. For night time cough relief 2 tsf at bedtime followed by 2 tsf every 6 hours. Hepatic dysfunction Subjects with moderate to severe hepatic dysfunction should exercise caution when using this product

Child Dose

Children>12 years and over: Syrup 2 tsf 4 times a day. For night time cough relief 2 tsf at bedtime followed by 2 tsf every 6 hours. Children<12 years: Safety & Efficacy not established

Renal Dose

Subjects with moderate to severe renal dysfunction should exercise caution when using this product

Administration

May be taken with or without food.

Contra Indications

Known hypersensitivity to the product or any of its constituents. Not to be used in children under the age of 12 years.

Precautions

This product should be not used for persistent or chronic cough, such as occurs with asthma, or where cough is accompanied by excessive secretion. May impair ability to drive or operate machinery. Should be used with caution in patients with narrow-angle glaucoma or symptomatic prostatic hypertrophy. Avoid alcohol.

Pregnancy-Lactation

Interactions

This product contains diphenhydramine and therefore may potentiate the effects of alcohol, codeine, antihistamines and other CNS depressants. As diphenhydramine possesses some anticholinergic activity, the effects of anticholinergics (e.g. some psychotropic drugs and atropine) may be potentiated by this product. This may result in tachycardia, dry mouth, gastrointestinal disturbances (e.g. colic), urinary retention and headache.

Side Effects

Side effects of Guaiphenesin + Diphenhydramine + Levomenthol : Diphenhydramine may cause drowsiness, dizziness, gastrointestinal disturbance; dry mouth nose and throat; difficulty in urination or blurred vision. Less frequently it may cause palpitations, tremor, convulsions or paraesthesia. Hypersensitivity reactions have been reported, in particular, skin rashes, erythema, urticaria and angiodema. Gastro-intestinal discomfort, nausea and vomiting have occasionally been reported with guaifenesin particularly in large doses. Adverse reactions to levomenthol at the low concentration present are not anticipated.

Mode of Action

Diphenhydramine is a potent antihistamine and antitussive with anticholinergic and sedative properties. Recent experiments have shown that the antitussive action is discrete from H1-receptor blockade and is located in the brain stem. Guaifenesin is reported to reduce the viscosity of tenacious sputum and is used as an expectorant. Levomenthol has mild local anaesthetic and decongestant properties.

Note

Kof-free 280 mg + 2000 mg + 22 mg/ Syrup generic name is Guaiphenesin + Diphenhydramine + Levomenthol. Kof-free 280 mg + 2000 mg + 22 mg/ Syrup is manufactured by Benham Pharmaceuticals Ltd.Kof-free is availble in all over Bangladesh. Mes BD drug index information on Kof-free Syrup is not intended for diagnosis, medical advice or treatment; neither intended to be a substitute for the exercise of professional judgment.

Some other brands of Guaiphenesin + Diphenhydramine + Levomenthol :

Syrup

Tusca Plus ^{(100mg +14mg + 1.1mg)}

Square Pharmaceuticals Ltd.

Syrup

Tuscof ^{200mg + 15mg + 15mg}

Eskayef Pharmaceuticals Ltd.

Syrup

Pires-M ^{100mg + 14mg + 1.1mg}

Navana Pharmaceuticals Ltd.

Syrup

Daykof Syrup ^{280 mg + 2000 mg + 22 mg/}

Beacon Pharmaceuticals Ltd.

Syrup

Nycof ^{280 mg + 2000 mg + 22 mg/}

Eskayef Pharmaceuticals Ltd.