Indications
Kanamycin-POS Eye Drops is used for:
Susceptible Infections
Adult Dose
Susceptible Infections
IV Administration: 5-7.5 mg/kg/dose divided q8-12hr; not to exceed 15 mg/kg/day divided q6-12hr; administer slowly
IM Administration: 5-7.5 mg/kg/dose divided q8-12hr; not to exceed 15 mg/kg/day IM divided q12hr at equally divided intervals; continuously high blood levels are desired; daily dose of 15 mg/kg may be given divided q6-8hr
Aerosol: 250 mg q6-12hr by nebulization
Child Dose
Renal Dose
Renal Impairment
CrCl 50-80 mL/min: give 60-90% of usual dose or give q8-12hr
CrCl 10-50 mL/min: give 30-70% of usual dose or give q12hr
CrCl <10 mL/min: give 20-30% of usual dose or give q24-48hr
Administration
IV Preparation
For adults, IV infusions are prepared by adding 500 mg of kanamycin to 100-200 mL of usual IV infusion fluid such as NS or D5W or by adding 1 g of the drug to 200-400 mL of diluent
IV/IM Administration
Administer by deep IM injection, or IV infusion
May administer by intraperitoneal instillation, irrigation, or inhalation
Infuse over 30-60 min
Contra Indications
Documented hypersensitivity
Precautions
Auditory toxicity more common with kanamycin than with streptomycin and capreomycin; monthly audiometry is recommended while patients are being treated with this drug; vestibular toxicity is rare; renal toxicity occurs at a frequency similar to that of capreomycin; regular monitoring of serum creatinine recommended
Neurotoxicity, manifested as both bilateral auditory and vestibular ototoxicity, can occur in patients with preexisting renal damage and in patients with normal renal function treated at higher doses and/or for periods longer than those recommended. High-frequency deafness usually occurs first and can be detected only by audiometric testing. Vertigo may occur and may be evidence of vestibular injury
Aminoglycosides are potentially nephrotoxic. Risk is greater in patients with impaired renal function and in those who receive high doses or prolonged therapy. Rarely, nephrotoxicity may not become apparent until the first few days after cessation of therapy
Use with caution in premature infants and neonates because of renal immaturity and the resulting prolongation of serum half-life of the drug
Pregnancy-Lactation
Pregnancy Category: D
Lactation: usually compatible
Interactions
Side Effects
Side effects of Kanamycin :
Frequency Not Defined
Agranulocytosis
Anorexia
Diarrhea
Dyspnea
Edema
Elevated BUN
Enterocolitis
Headache
Incr salivation
Muscle cramps
Muscle weakness
Nausea
Nephrotoxicity
Neurotoxicity
Ototoxicity
Pruritus
Pseudotumor cerebri
Rash
Tinnitus
Thrombocytopenia
Tremor
Vertigo
Weakness
Mode of Action
Bactericidal
Aminoglycoside contain 1 or 2 amino sugars linked to an aminocyclitol nucleus. Nucleus is 2-deoxystreptamine. Bactericidal and believed to inhibit protein synthesis by binding to 30 S ribosomal subunit.
Note
Kanamycin-POS 0.50% Eye Drops generic name is Kanamycin. Kanamycin-POS 0.50% Eye Drops is manufactured by ZAS CorporationKanamycin-POS is availble in all over Bangladesh.
Mes BD drug index information on Kanamycin-POS Eye Drops is not intended for diagnosis, medical advice or treatment; neither intended to be a substitute for the exercise of professional judgment.