Immunohbs Injection
Hepatitis b immunoglobulin
180 IU/ml
ZAS Corporation
| Pack size | 180 IU |
|---|---|
| Unite Price | 5430.00 BDT |
Indications
Immunohbs Injection is used for:
Passive immunisation against hepatitis B infection, Prophylaxis of hepatitis B recurrence after liver transplantation
Adult Dose
Intramuscular
Passive immunisation against hepatitis B infection
Adult: 500 IU given as a single dose, given preferably within 48 hr of exposure and not >1 wk after exposure. Contents of hepatitis B immunoglobulin may vary between countries and between manufacturers (see lit). Caution should be taken in interpreting dosage recommendations which are not given in terms of IU.
Intravenous
Prophylaxis of hepatitis B recurrence after liver transplantation
Adult: Given in doses of 20,000 IU/dose: Initially, 1 dose with liver transplant.
In the 1st wk post-operation: 1 dose daily for 7 days (day 1-7);
from wk 2-12 post-operation (starting from day 14): 1 dose every 2 wk;
from 4th mth onwards: 1 dose mthly. Adjust dose to reach anti-HBs levels of 500 IU/L within the 1st wk post-transplantation.
For patients with surgical bleeding, abdominal fluid drainage >500 ml or those undergoing plasmapheresis, 10,000 IU should be given every 6 hr until target anti-HBs levels are reached.
Contents of hepatitis B immunoglobulin may vary between countries and between manufacturers. Caution should be taken in interpreting dosage recommendations which are not given in terms of IU.
Child Dose
Intramuscular
Passive immunisation against hepatitis B infection
Child: <5 yr: 200 IU; 5-9 yr: 300 IU; >10 yr: 500 IU. To be given as a single dose, preferably within 48 hr of exposure and not >1 wk after exposure.
For newborns (whose mothers are persistent carriers of hepatitis B surface antigen (HbsAg) or mothers who are HBsAg-positive as a result of recent infection): 200 IU at birth or within 24 hr after birth.
Contents of hepatitis B immunoglobulin may vary between countries and between manufacturers. Caution should be taken in interpreting dosage recommendations which are not given in terms of IU.
Renal Dose
Administration
Contra Indications
Hypersensitivity; severe allergy to gamma globulin or anti-immunoglobulin therapies. IM inj in patients with thrombocytopenia or coagulation disorders.
Precautions
Patients with thrombocytopenia or coagulation disorders. May contain certain infectious agents that could transmit disease. Hepatitis B immunoglobulins may be administered at the same time (but at a different site) or up to 1 mth before hepatitis B vaccination without compromising the active immune response. Human hepatitis B immunoglobulin should not be administered via IV inj. May cause drowsiness. Monitor for infusion-related adverse events. Pregnancy and lactation.
Pregnancy-Lactation
Pregnancy Category: C
Lactation: Not known if excreted in breast milk
Interactions
May interfere with immune response when used with live vaccines; live vaccines should be given only 3 mth after admin of immunoglobulin.
Side Effects
Side effects of Hepatitis b immunoglobulin :
Fainting, headache, lightheadedness, malaise, angioedema, bruising, urticaria, nausea, vomiting, increased AST and alkaline phosphatase. Ache, pain, erythema, and/or tenderness at inj site. Anaphylaxis, cold/flu-like syndrome, arthralgia, joint stiffness and myalgia.
Mode of Action
Hepatitis B immunoglobulins contain specific neutralising antibodies (mainly IgG) that provide passive immunisation for individuals exposed to the hepatitis B virus. It is used for post-exposure prophylaxis in persons who are not vaccinated, or whose prior vaccination regimen is incomplete or when the antibody level is <10 IU/ml. It may also be used in haemodialysis patients and receptors of certain blood products who are unable to develop adequate immune protection.
Note
Immunohbs 180 IU/ml Injection generic name is Hepatitis b immunoglobulin. Immunohbs 180 IU/ml Injection is manufactured by ZAS CorporationImmunohbs is availble in all over Bangladesh.
Mes BD drug index information on Immunohbs Injection is not intended for diagnosis, medical advice or treatment; neither intended to be a substitute for the exercise of professional judgment.