Hemosin Injection

Aminocaproic Acid
1 gm/5 ml
Chemist Laboratories Ltd.
Pack size 5 ml
Unite Price 15.17 BDT

Indications

Hemosin Injection is used for: Haemorrhage, Missed abortion, Hereditary hemorrhagic telangiectasia,Traumatic hyphema, Dental bleeding, Hemophilia A, Postoperative bleeding, Systemic hyperfibrinolysis

Adult Dose

Intravenous Treatment and prophylaxis of haemorrhage Adult: Initially, 4-5 g as a 2% solution over 1 hr followed by a 1 g/hr infusion continued for up to 8 hr or until bleeding has been controlled. Max: 24 g in 24 hr. Oral Treatment and prophylaxis of haemorrhage Adult: Initially, 4-5 g, followed by 1-1.25 g every hr for about 8 hr or until bleeding has been controlled. Max: 24 g in 24 hr. Patients with haemophilia undergoing dental extraction Adult: Initially, 6 g immediately after the procedure, followed by 6 g every 6 hr for up to 10 days.

Child Dose

Renal Dose

Renal impairment: Dosage reduction may be required.

Administration

IV Administration Initial 5 g in 250 mL over 1 hr, each subsequent gram in 50-100 mL at 1 g/hr Rapid injection undiluted into a vein is not recommended Continue for about 8 hr or until bleeding has been controlled Oral May be taken with or without food. May be taken w/ meals to prevent GI upset.

Contra Indications

Bleeding due to disseminated intravascular coagulation. Rapid IV administration.

Precautions

Renal or cardiac disorders. Urinary tract bleeding, haematuria of upper urinary tract origin; veno-occlusive hepatic disease, skeletal myopathy, neonates. Monitor creatinine phosphokinase. Avoid admin with factor IX complex concentrates. Pregnancy and lactation. Lactation: not known whether excreted in breast milk, use caution

Pregnancy-Lactation

Pregnancy Category: C Lactation: Not known whether excreted in breast milk, use caution

Interactions

Increased risk of hypercoagulability with OC and oestrogens.

Side Effects

Side effects of Aminocaproic Acid : Oedema, headache, malaise, allergic and anaphylactic reactions, anaphylaxis, bradycardia, hypotension, peripheral ischaemia, thrombosis, abdominal pain, diarrhoea, nausea, vomiting, agranulocytosis, coagulation disorder, leukopaenia, thrombocytopaenia, increased CPK, muscle damage, myalgia, myopathy, myositis, rhabdomyolysis, confusion, convulsions, delirium, dizziness, hallucinations, intracranial hypertension, stroke, syncope, dyspnoea, nasal congestion, pulmonary embolism, pruritus, rash, tinnitus, decreased vision, watery eyes, increased BUN, dry ejaculation. Potentially Fatal: Cardiac and hepatic damage.

Mode of Action

Aminocaproic acid inhibits the action of plasminogen activators and, to a lesser extent, it also has some antiplasmin activity.

Note

Hemosin 1 gm/5 ml Injection generic name is Aminocaproic Acid. Hemosin 1 gm/5 ml Injection is manufactured by Chemist Laboratories Ltd.Hemosin is availble in all over Bangladesh. Mes BD drug index information on Hemosin Injection is not intended for diagnosis, medical advice or treatment; neither intended to be a substitute for the exercise of professional judgment.

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