G-Thiazide T Tablet
Hydrochlorothiazide + Triamterene
Gonoshasthaya Pharmaceuticals Ltd.
| Pack size | 100's pack |
|---|---|
| Unite Price | 0.52 BDT |
Indications
G-Thiazide T Tablet is used for:
Hypertension, Oedema
Adult Dose
Hypertension
1-2 tablets/capsules (37.5-50 mg triamterene and 25 mg HCTZ) PO qDay
1 tablet (75 mg triamterene and 50 mg HCTZ) PO qDay
Dosing considerations
Monitor serum potassium
Edema
1-2 tablets/capsules (37.5-50 mg triamterene and 25 mg HCTZ) PO qDay
1 tablet (75 mg triamterene and 50 mg HCTZ) PO qDay
Child Dose
Safety and efficacy not established
Renal Dose
Administration
Should be taken with food. Take after meals.
Contra Indications
severe renal or hepatic impairment, preexisting or drug-induced hyperkalemia, patients at risk of respiratory or metabolic acidosis. Lactation.
Precautions
Renal and hepatic impairment; cirrhosis; DM; hyponatraemia; hyperuricaemia; history of nephrolithiasis; depleted folic acid stores. Monitor electrolyte concentrations closely, especially potassium levels. Observe for signs of liver damage, blood dyscrasias or other idiosyncratic reactions. Discontinue treatment if urinary calculus is passed. Pregnancy and elderly.
Lactation: Not recommended; discontinue drug or do not nurse
Pregnancy-Lactation
Pregnancy category: C
Lactation: Not recommended; discontinue drug or do not nurse
Interactions
May enhance toxicity of digitalis glycosides, neuromuscular-blocking action of competitive muscle relaxants, effect of antihypertensives. Increased risk of postural hypotension w/ alcohol, barbiturates, opioids. K-depleting effect enhanced by corticosteroids, lithium, ACTH, carbenoxolone.
Side Effects
Side effects of Hydrochlorothiazide + Triamterene :
Triamterene
Jaundice, Weaknes, Headache, Azotemia, Dizziness, Fatigue, Xerostomia, Photosensitivity, Rash, Diarrhea, Nausea, Vomiting, Hyperuricemia, Hyper/hypokalemia, Interstitial nephritis
Hydrochlorothiazide
Anorexia, Epigastric distress, Hypotension, Orthostatic hypotension, Photosensitivity, Anaphylaxis, Anemia, Confusion, Erythema multiforme, Stevens-Johnson syndrome, Exfoliative dermatitis including toxic epidermal necrolysis, Dizziness, Hypokalemia and/or hypomagnesemia, Hyperuricemia
Mode of Action
Hydrochlorothiazide inhibits the reabsorption of Na and chloride in the distal tubules causing increased excretion of Na and water K and hydrogen ions.
Triamterene is a potassium sparing diuretic which appears to act mainly on the distal renal tubules. It increases the excretion of Na and reduces the excretion of potassium. It adds to the natriuretic but reduces the kaliuretic effects of other diuretics. It is structurally similar to folate and has anti-folate activity.
Note
G-Thiazide T Tablet generic name is Hydrochlorothiazide + Triamterene. G-Thiazide T Tablet is manufactured by Gonoshasthaya Pharmaceuticals Ltd.G-Thiazide T is availble in all over Bangladesh.
Mes BD drug index information on G-Thiazide T Tablet is not intended for diagnosis, medical advice or treatment; neither intended to be a substitute for the exercise of professional judgment.