Indications
Furamane Capsule is used for:
Insomnia
Adult Dose
Oral
Short-term management of insomnia
Adult: 15-30 mg at night.
Elderly: Max: 15 mg at night.
Child Dose
Oral
Short-term management of insomnia
Child: >15 yr 15 mg at night.
Elderly: Max: 15 mg at night.
Renal Dose
Administration
May be taken with or without food.
Contra Indications
Hypersensitivity; porphyria. Pregnancy (3rd trimester); neonates.
Precautions
Chronic pulmonary insufficiency; elderly or debilitated patients; muscle weakness, impaired liver or kidney function; drowsiness may affect skilled tasks; monitor cardio-respiratory function when used for deep sedation; personality disorders or organic brain changes; history of alcohol or drug addiction. Respiratory depression and hypotension with parenteral admin. Dependence; lactation. Safety and efficacy are not proven in children <15 yr.
Lactation: Excretion in milk unknown; not recommended
Pregnancy-Lactation
Pregnancy Category: X
Lactation: Excretion in milk unknown; not recommended
Minor tranquilizers should be avoided in 1st trimester of pregnancy due to increased risk of congenital malformations
Maternal use shortly before delivery is associated with floppy infant syndrome (good and consistent evidence)
Prenatal benzodiazepine exposure slightly increased oral cleft risk (limited or inconsistent evidence)
Interactions
May enhance CNS depressant effect w/ antidepressants, antipsychotics, general anaesth, hypnotics or sedatives, opioid analgesics. Flurazepam clearance may be reduced by cimetidine, and may be increased by rifampicin.
Side Effects
Side effects of Flurazepam :
Common
Ataxia, Dizziness, Drowsiness, Lethargy, Light-headedness
Less Common
Chest pain, palpitations, Headache, irritability, nervousness, weakness, GI complaints, Myalgia, GU complaints
Rare
Elevations of AST, ALT, bilirubin (T&D), alk phos
Mode of Action
Flurazepam is a long-acting benzodiazepine which binds to stereospecific benzodiazepine receptors on the postsynaptic GABA neuron w/in the CNS, including the limbic system, reticular formation. It enhances the inhibitory effect of GABA on neuronal excitability by increasing neuronal membrane permeability to Cl ions, thus resulting in hyperpolarisation and stabilisation.
Note
Furamane 15mg Capsule generic name is Flurazepam. Furamane 15mg Capsule is manufactured by G. A. Company Ltd.Furamane is availble in all over Bangladesh.
Mes BD drug index information on Furamane Capsule is not intended for diagnosis, medical advice or treatment; neither intended to be a substitute for the exercise of professional judgment.