Indications
Folinic Tablet is used for:
Methotrexate Overdose, Methanol Poisoning,
Trimethoprim Toxicity
Adult Dose
Methotrexate Overdose
1:1 ratio for leucovorin to inadvertent methotrexate overdose, within 1 hr
Initial IV, then may switch to IM q6hr and continue until methotrexate level has fallen below 0.05 micromolar and the renal failure has resolved
High Dose Methotrexate Rescue
10 mg/m² IV q6hr starting 24 hr after methotrexate
May give PO after 1st IV dose
Methanol Poisoning
1 mg/kg (50-70 mg adults) IV q4-6hr
Trimethoprim Toxicity
10 mg/m² PO q6hr
Child Dose
Renal Dose
Administration
IV Preparation
Reconstitute w/ BWI or SWI of 10 mg/mL or 20 mg/mL (for 350 mg vial)
Available in 10 mg/mL preservative-free solutions
Do not use benzyl alcohol-containing diluents for doses >10 mg/sq.meter
Reconstituted solution is stable for 7 d
Use immediately if reconstituted w/ preservative-free solution
IV/IM Administration
Infusion: not to exceed 160 mg/min
Contra Indications
Vitamin B12 deficiency anemia and pernicious anemia
Precautions
Hypersensitivity reactions including anaphylactoid reactions & urticaria
Risk of severe neurological complications in patients with undiagnosed anemia
Geriatric or debilitated patients receiving cotreatment with fluorouracil
May increase tosicity of 5-fluorouracil
May increase treatment failure of sulfamethoxazole-trimethoprim therapies
Formulations containing benzyl alcohol not to be used in infants
Thrombocytosis reported during intra-arterial infusion of methotrexate
Pregnancy-Lactation
Pregnancy Category: C
Lactation: not known whether distributed in breast milk; use caution
Interactions
Side Effects
Side effects of Leucovorin :
Frequency Not Defined
Diarrhea
Nausea
Vomiting
Stomatitis
Thrombocytosis
Anaphylactoid reaction
Wheezing
Urticaria
Anaphylactoid reactions
Mode of Action
Serves as a cofactor supplement to counteract folic acid antagonists such as methotrexate; leucovorin is an active metabolite of folic acid
Displaces methotrexate from intracellular binding sites and restores the folate required for DNA/RNA synthesis
In methanol toxicity it serves as a tetrahydrofolate source to help the body eliminate the formic acid resulting from methanol's toxicity
Note
Folinic 5mg Tablet generic name is Leucovorin. Folinic 5mg Tablet is manufactured by Renata LimitedFolinic is availble in all over Bangladesh.
Mes BD drug index information on Folinic Tablet is not intended for diagnosis, medical advice or treatment; neither intended to be a substitute for the exercise of professional judgment.