Indications
Fluzin 10 Tablet is used for:
The main indications for flunarizine are the prophylaxis of migraine headaches and the treatment of vertigo (a sensation of spinning or swaying). It may also be used to treat other conditions such as Meniere's disease, a disorder of the inner ear that causes vertigo, hearing loss, and tinnitus, and also used in the treatment of motion sickness.
It is also used as an adjunctive therapy in the treatment of epilepsy, and in some cases it has been used to treat anxiety and insomnia.
Adult Dose
Flunarizine is used orally for preventing migraines, vertigo, vestibular disorders, peripheral and cerebrovascular disorders in adults. The typical dose is 5-10 mg per day, usually taken at night to reduce drowsiness.
For migraine prevention, the starting dose for patients under 65 is 10 mg per day at night and for patients over 65 is 5 mg per day.
For maintenance treatment, if the patient's response is positive, the dose may be decreased to a regimen of 5 days of treatment per week with 2 consecutive drug-free days. Treatment should be discontinued after 6 months and only resumed if the patient relapses. The recommended maximum daily dose is 10 mg per day for adults.
For vertigo and motion sickness, the recommended maximum daily dose is 10 mg per day for adults. For peripheral vascular disorders, the recommended daily dose is 5-10 mg in the evening. For epilepsy, an optimal therapeutic dosage in combination with other anti-epileptic drugs is 15-20 mg per day for adults.
Child Dose
Oral
Prophylaxis of migraine; Prophylaxis of vertigo and vestibular disorders; Prophylaxis of peripheral and cerebrovascular disorders
Child:
The usual dose is 5 mg daily, usually given at night to minimize the effects of drowsiness.
Maintenance treatment: If a patient’s response is satisfactory and if a maintenance treatment is needed, the dose should be decreased to 5 days (of a week) treatment at the same daily dose and 2 successive drug free days. Treatment should be interrupted after 6 months and re-initiated only if the patient relapses. The recommended maximum daily dose is 5 mg daily in children (< 40 kg).
For vertigo and motion sickness : The recommended maximum daily dose of Flunarizine in the treatment of vertigo is 5 mg daily in children ( < 40 kg).
For epilepsy: An optimal therapeutic dosage in epileptic patients receiving other anti-epileptic drugs is 5 to 10 mg daily in children.
Renal Dose
Administration
Flunarizine is typically administered orally, in the form of a tablet. It is usually taken once a day, at night, to minimize the drowsiness that can be a side effect of the medication. The dosage may vary depending on the condition being treated and the individual patient, with the recommended daily dose ranging from 5-10 mg in adults.
Contra Indications
Pregnancy and breastfeeding: Flunarizine should not be used by women who are pregnant or breastfeeding as it may harm the unborn or nursing baby.
Depression: People who have a history of depression should not take flunarizine as it may worsen their condition.
Allergy: If you are allergic to flunarizine or any other ingredient in the medication, you should not take it.
Cardiac disease: Flunarizine may cause side effects on the heart and should be used with caution in people with heart disease.
Liver or kidney problems: Flunarizine is metabolized by the liver and excreted by the kidneys, so it should be used with caution in people with liver or kidney problems.
Parkinson's disease: People with Parkinson's disease should not take flunarizine as it may worsen their condition.
Other medications: Flunarizine may interact with other medications and may cause side effects, so it is important to tell your healthcare professional about all the medications you are taking.
Precautions
Flunarizine may lead to drowsiness which is aggravated by the simultaneous intake of alcohol or other central nervous system depressants. Patients should avoid driving motor vehicles or performing other potentially hazardous tasks where a loss of mental alertness may lead to accidents. Flunarizine should therefore be used with caution in such patients.
Pregnancy-Lactation
The safety of Flunarizine for use in pregnancy and lactation has not been established.
Interactions
Galactorrhea has been reported in few women on oral contraceptives within the first two months of Flunarizine treatment. Hepatic enzyme inducers such as carbamazepine and phenytoin increase the metabolism of Flunarizine. So an increase in dose of the drug may be required. Concomitant use of a calcium channel blocker and amiodarone has been reported to result in sinus arrest and atrioventricular block.
Side Effects
Side effects of Flunarizine :
Drowsiness. Rarely wt gain, headache, depression, gastric pain, dry mouth, insomnia, extrapyramidal reactions, galactorrhoea.
Mode of Action
Flunarizine has H1-receptor blocking action and calcium-channel blocking effect. It has also been used as an adjunct epileptic therapy for patients refractory to standard treatment regimens.
Note
Fluzin 10 10mg Tablet generic name is Flunarizine. Fluzin 10 10mg Tablet is manufactured by Acme Laboratories Ltd.Fluzin 10 is availble in all over Bangladesh.
Mes BD drug index information on Fluzin 10 Tablet is not intended for diagnosis, medical advice or treatment; neither intended to be a substitute for the exercise of professional judgment.