Fluvas Capsule
Fluvastatin
20mg
Silva Pharmaceuticals Ltd.
| Pack size | 12's pack |
|---|---|
| Unite Price | 12.05 BDT |
Indications
Fluvas Capsule is used for:
Hyperlipidaemias, Hypercholesterolemia
Adult Dose
Oral
Hypercholesterolemia & Mixed Dyslipidemia
Adult: Initially, 20-40 mg once daily in the evening, may increase at intervals of 4 wk to max 80 mg/day in 12hrly divided dose.
Hepatic Impairment
Contraindicated in active liver disease or unexplained transaminase elevations
Child Dose
Oral
Hyperlipidaemias
Child: Heterozygous familial hypercholesterolaemia: 10-16 yr 20 mg once daily. If necessary, may increase dose at 6-wkly intervals to 40 mg bid or 80 mg once daily as modified-release.
Renal Dose
Renal Impairment
CrCl <30 mL/min: Adjust dose amount; not to exceed 40 mg/day
Administration
May be taken with or without food.
Contra Indications
Acute liver disease; unexplained persistently raised serum aminotransferase concentrations; porphyria; pregnancy; lactation.
Precautions
History of liver disease; high alcohol intake. Manage hypothyroidism adequately before starting treatment. Report unexplained muscle pain. Monitor LFTs. Discontinue in case of marked or persistent increase in serum aminotransferase or creatine phosphokinase. Severe renal impairment.
Lactation: enters breast milk; contraindicated
Pregnancy-Lactation
Pregnancy Category: X
Lactation: enters breast milk; contraindicated
Interactions
Bleeding and increased prothrombin time w/ coumarin anticoagulants. May increase the risk of myopathy and rhabdomyolysis w/ HIV protease inhibitors, colchicine, bezafibrate, ciprofibrate or niacin (nicotinic acid), ciclosporin and fluconazole. Reduced bioavailability w/ concomitant rifampicin.
Side Effects
Side effects of Fluvastatin :
1-10%
Headache (9%), Dyspepsia (8%), Abdominal pain (5%), Diarrhea (5%), Myalgia (5%), Fatigue (3%), Insomnia (3%), Nausea (3%), Sinusitis (3%), Bronchitis (2%), UTI (2%), Transaminases increased (1.1%)
<1%
Rash, Back pain, Arthralgia, Myopathy, Rhabdomyolysis, Rupture of tendon, CPK increased, Pharyngitis, Rhinitis, Cough, Constipation, Pancreatitis, Dizziness
Mode of Action
Fluvastatin acts by competitively inhibiting HMG-CoA reductase, the enzyme for cholesterol synthesis. It reduces total cholesterol, triglycerides, LDL and VLDL concentrations in plasma. It also increases HDL concentrations.
Note
Fluvas 20mg Capsule generic name is Fluvastatin. Fluvas 20mg Capsule is manufactured by Silva Pharmaceuticals Ltd.Fluvas is availble in all over Bangladesh.
Mes BD drug index information on Fluvas Capsule is not intended for diagnosis, medical advice or treatment; neither intended to be a substitute for the exercise of professional judgment.