Fexotab Plus ER Extended Release Tablet
Fexofenadine Hydrochloride + Pseudoephedrine Hydrochloride
60 mg + 120 mg
Veritas Pharmaceuticals Ltd.
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Indications
Fexotab Plus ER Extended Release Tablet is used for:
Allergic rhinitis, Hay fever, Urticaria, Sneezing, Runny nose, Hives, Skin rash, Common cold, Allergy, Itchy or watery eyes, Nasal congestion
Adult Dose
Oral
Seasonal Allergic Rhinitis with Nasal Congestion
Adult: 1 tab 60 mg fexofenadine/120 mg pseudoephedrine PO BID
Child Dose
Child: >12 yr: 1 tab bid.
<12 years: Safety and efficacy not established
Renal Dose
Renal Impairment
Avoid
Administration
Take on empty stomach with water only
Swallow whole; do not chew, crush, or split tablet
Contra Indications
Severe hypertension, phaeochromocytoma.
Precautions
Hyperthyroidism; ischaemic heart disease, arrhythmia or tachycardia; occlusive vascular disorders e.g. arteriosclerosis, hypertension or aneurysms; DM and closed-angle glaucoma; renal impairment, prostatic enlargement. Pregnancy; lactation.
Lactation: avoid, not known if enters breast milk
Pregnancy-Lactation
Pregnancy Category: C
Lactation: avoid, not known if enters breast milk
Interactions
Increased risk of hypertension and arrhythmias if given with cardiac glycosides, quinidine or TCAs. Increased risk of vasoconstrictor effects if given with ergot alkaloids or oxytocin. Co-admin with MAOIs may cause hypertensive crisis. Anaesthetics e.g. cyclopropane, halothane and other halogenated anaesthestics; antihypertensive agents.
Side Effects
Side effects of Fexofenadine Hydrochloride + Pseudoephedrine Hydrochloride :
1-10%
Headache (7.2%), Drowsiness (1.3%), Fatigue (1.3%)
Frequency Not Defined
CNS depression, Sedation ranging from mild drowsiness to deep sleep (most frequent), Dizziness, Lassitude, Disturbed coordination, Muscular weakness, Restlessness, insomnia, tremors, euphoria, nervousness, delirium, palpitation, seizures is less common, Epigastric distress, Anorexia, Nausea, Vomiting, Diarrhea, Constipation, Cholestasis, hepatitis, hepatic failure, hepatic function abnormality, jaundice is rare, Tachycardia, palpitation ECG changes (eg, widened QRS).
Arrhythmias (eg, extrasystole, heart block), Hypotension, Hypertension, Dizziness, sedation, and hypotension may occur in geriatric patients, Dryness of mouth, nose, and throat, Dysuria, Urinary retention, Impotence, Vertigo, Visual disturbances, Blurred vision, Diplopia; tinnitus, Acute labyrinthitis, Tremors, Nervousness, Irritability, Facial dyskinesia, Tightness of the chest, Thickening of bronchial secretions, Wheezing, Nasal stuffiness, Sweating, Chills, Early menses, Toxic psychosis, Faintness, Paresthesia, Agranulocytosis, Hemolytic anemia, Leukopenia, Thrombocytopenia, Pancytopenia, Dysmenorrhea, Dyspepsia, Fatigue, Ischemic colitis (pseudoephedrine)
Mode of Action
Fexofenadine, an active metabolite of terfenadine, is a competitive peripheral histamine H1-receptor antagonist on effector cells in the GI tract, blood vessels and respiratory tract.
Pseudoephedrine is both an alpha-and beta-adrenergic receptor agonist. It causes vasoconstriction via direct stimulation of alpha-adrenergic receptors of the respiratory mucosa. It also directly stimulates beta-adrenergic receptors causing bronchial relaxation, increased heart rate and contractility.
Note
Fexotab Plus ER 60 mg + 120 mg Extended Release Tablet generic name is Fexofenadine Hydrochloride + Pseudoephedrine Hydrochloride. Fexotab Plus ER 60 mg + 120 mg Extended Release Tablet is manufactured by Veritas Pharmaceuticals Ltd.Fexotab Plus ER is availble in all over Bangladesh.
Mes BD drug index information on Fexotab Plus ER Extended Release Tablet is not intended for diagnosis, medical advice or treatment; neither intended to be a substitute for the exercise of professional judgment.