Indications
Fexib Tablet is used for:
Osteoarthritis, Rheumatoid arthritis, Pain
Adult Dose
Oral
Osteoarthritis
Adult: Initially, 12.5 mg once daily. Max: 25 mg/day.
Pain relief
Adult: Initially, 50 mg once daily followed by daily doses of 25-50 mg. Max: 50 mg/day. Treatment duration >5days is not recommended.
Rheumatoid arthritis
Adult: 25 mg daily. Max: 25 mg/day.
Hepatic Impairment Max: 12.5 mg/day.
Child Dose
Renal Dose
Administration
Contra Indications
Hypersensitivity. Severe renal impairment.
Precautions
Hepatic dysfunction, pregnancy and lactation. History of ulcer disease or GI bleeding. Elderly or debilitated patients. Prolonged treatment, smoking and alcoholism may increase risk of GI bleeding. Ischaemic heart disease.
Pregnancy-Lactation
Pregnancy Category C, D (in 3rd trimester or near delivery)
Interactions
Side Effects
Side effects of Rofecoxib :
Mouth ulcers, chest pain, weight gain, atopic eczema, muscle cramps, diarrhoea, headache, nausea; upper respiratory tract infection, hypertension, ischaemia, dyspepsia, epigastric discomfort, heart burn, nausea, sinusitis, back pain, headache, bronchitis, urinary tract infections.
Potentially Fatal: Renal failure; nephrotoxicity; MI.
Mode of Action
Rofecoxib is a nonsteroidal anti-inflammatory drug (NSAID) that exhibits anti-inflammatory, analgesic, and antipyretic activities in animal models. The mechanism of action of (rofecoxib) is believed to be due to inhibition of prostaglandin synthesis, via inhibition of cyclooxygenase-2 (COX-2).
Note
Fexib 12.5mg Tablet generic name is Rofecoxib. Fexib 12.5mg Tablet is manufactured by Renata LimitedFexib is availble in all over Bangladesh.
Mes BD drug index information on Fexib Tablet is not intended for diagnosis, medical advice or treatment; neither intended to be a substitute for the exercise of professional judgment.