Fenazine Injection
Fluphenazine Decanoate
25mg/ml
Incepta Pharmaceuticals Ltd.
| Pack size | 5 amps pack |
|---|---|
| Unite Price | 75.00 BDT |
Indications
Fenazine Injection is used for:
In the long-term management of psychotic disorders including, Schizophrenia, Mania, Organic brain syndrome
Adult Dose
Intramuscular
Psychoses; Mania; Schizophrenia
Adult: As decanoate: Initially, 12.5 mg adjusted according to response. Maintenance: 12.5-100 mg at intervals of 2-6 wk. For doses >50 mg, increments should be made slowly in steps of 12.5 mg.
Elderly: 6.25 mg adjusted according to response.
Hepatic impairment: Use with caution; monitor
Child Dose
Safety and efficacy not established
Renal Dose
Renal impairment: Use with caution; monitor
Administration
Contra Indications
Fluphenazine Decanoate oily Injection is contraindicated in patients with hypersensitivity to the drug. Also contraindicated in comatose or severely depressed states, blood dyscrasias, liver disease, pregnancy (3rd trimester), lactation.
Precautions
Special precaution should be practiced in presence of convulsive disorders; hepatic, renal, cerebrovascular, respiratory and cardiovascular diseases. Also precaution should be observed in case of phenochromocytoma; bone marrow suppression; elderly or debilitated patients.
Lactation: Drug enters breast milk; not recommended
Pregnancy-Lactation
Interactions
Reduces antihypertensive effects of guanethidine, methyldopa and clonidine. Lithium toxicity. Reduced bioavailability with antacids. Increased risk of arrhythmia when used with drugs that prolong QT interval. May cause electrolyte disturbance when used with diuretics.
Potentially Fatal: Additive CNS depressant effects with alcohol, barbiturates, hypnotics, sedatives, opiates and antihistamines.
Side Effects
Side effects of Fluphenazine Decanoate :
Frequency Not Defined
Confusion, Decreased gag reflex
Extrapyramidal symptoms
Akathisia, Dystonia, Dyskinesia, Muscle stiffness, Neuroleptic malignant syndrome (NMS; infrequent but serious), Parkinsonism, Tardive dyskinesia
Common
Anticholinergic effects, Sedation, Weight gain, Erectile dysfunction, Oligomenorrhea or amenorrhea,
Less common
Orthostatic hypotension (after IM injection), tachycardia, Agitation, anxiety, cerebral edema, depression, dizziness, euphoria, headache, poikilothermia, restlessness, weakness, Anorexia, constipation, dyspepsia, ileus, Lens opacities (with prolonged use)
Uncommon
ECG changes, Photosensitivity, Pruritus, Diarrhea, Blood dyscrasia, Galactorrhea, Ejaculatory disorder
Rare
Seizure, Priapism, Cholestatic jaundice
Mode of Action
Fluphenazine blocks postsynaptic dopamine D1 and D2 receptors in the mesolimbic system and decreases the release of hypothalamic and hypophyseal hormones. It reduces aggressiveness with disappearance of hallucinations and delusions.
Note
Fenazine 25mg/ml Injection generic name is Fluphenazine Decanoate. Fenazine 25mg/ml Injection is manufactured by Incepta Pharmaceuticals Ltd.Fenazine is availble in all over Bangladesh.
Mes BD drug index information on Fenazine Injection is not intended for diagnosis, medical advice or treatment; neither intended to be a substitute for the exercise of professional judgment.