Ezyfast Tablet
Sodium polystyrene sulfonate
10 mg
Albion Laboratories Ltd.
| Pack size | 30's pack |
|---|---|
| Unite Price | 10.00 BDT |
Indications
Ezyfast Tablet is used for:
Hyperkalemia
Adult Dose
Oral
Hyperkalaemia
Adult: As suspension in water or syrup or as sweetened paste: 15 g up to 4 times daily. Not to be taken with fruit juices that have high potassium content.
Rectal
Hyperkalaemia
Adult: As enema (suspension): 30 g in 100 ml of 2% methylcellulose '450' and 100 ml of water, retained for at least 9 hr, if possible. Higher doses may be retained for a shorter period of time. Irrigate colon after retention to remove the resin.
Child Dose
Oral
Hyperkalaemia
Child: Acute hyperkalaemia: 1 g/kg daily in divided doses. Maintenance: 500 mg/kg daily.
Rectal
Hyperkalaemia
Child: and neonates: Acute hyperkalaemia: 1 g/kg daily in divided doses. Maintenance: 500 mg/kg daily.
Renal Dose
Administration
Oral Preparation
For each gram of powdered resin add 3-4 mL of water or syrup
Do not heat solution to improve dissolution; heat impairs resin exchange
Rectal Preparation
Suspend dose in 100 mL of aqueous liquid (eg, water, sorbitol 25%, methylcellulose 1%, dextrose 10%)
Oral Administration
Shake suspension well before administering
Administer PO or via NG tube with patient in upright position
Do not take other oral medications within 3 hr of dosing (6 hr for patients with gastroparesis or other conditions) because of potential GI binding
Do not mix with potassium containing liquids or food (eg, orange juice, bananas)
Suspension may be chilled to improve palatability
Rectal Administration
Administer cleansing enema beforehand
Administer sodium polystyrene sulfonate as warm emulsion (body temperature)
Gently agitate suspension during administration
Retain in colon for at least 30-60 min (several hours if possible)
After completing retention, use nonsodium colonic irrigant to remove remaining resin
Contra Indications
Hypersensitivity to polystyrene sulfonate resins. Oral admin to neonates; neonates with reduced gut motility; obstructive bowel disease. Hypokalaemia.
Precautions
Renal failure and conditions requiring a restricted sodium intake e.g. heart failure and severe hypertension. Rectal admin to neonates and children. Monitor for electrolyte disturbances and symptoms of hypokalaemia. Discontinue treatment if clinically significant constipation develops. Irrigate colon after admin of enema to ensure removal of resin. Pregnancy; lactation.
Lactation
Not absorbed systemically by the mother, so breastfeeding is not expected to result in risk to the infant
Pregnancy-Lactation
Pregnancy
Not absorbed systemically following oral or rectal administration and maternal use is not expected to result in fetal risk
Lactation
Not absorbed systemically by the mother, so breastfeeding is not expected to result in risk to the infant
Interactions
Reduces absorption of thyroxine and lithium salts. Enhances adverse effects of cardiac glycosides. Potassium-lowering effect may be reduced when used with other cation-containing antacids.
Side Effects
Side effects of Sodium polystyrene sulfonate :
1-10%
GI disturbance
Constipation
Hypokalemia
Hypocalcemia
Hypomagnesemia
Sodium retention
Nausea
Vomiting
Frequency Not Defined
GI concretions (bezoars) after oral use
GI tract ulceration or necrosis, which could lead to perforation
Fecal impaction after rectal administration (especially in children)
Acute bronchitis or bronchopneumonia associated with inhalation of polystyrene particles (rare)
Mode of Action
Sodium polysytrene sulfonate exchanges sodium ions for potassium ions and other cations in the GI tract before the resin is excreted in the faeces.
Note
Ezyfast 10 mg Tablet generic name is Sodium polystyrene sulfonate. Ezyfast 10 mg Tablet is manufactured by Albion Laboratories Ltd.Ezyfast is availble in all over Bangladesh.
Mes BD drug index information on Ezyfast Tablet is not intended for diagnosis, medical advice or treatment; neither intended to be a substitute for the exercise of professional judgment.