Ezipas Capsule
Tamsulosin Hydrochloride
400mcg
Leon Pharmaceuticals Ltd.
| Pack size | |
|---|---|
| Unite Price | 10.03 BDT |
Indications
Ezipas Capsule is used for:
Benign prostatic hyperplasia
Adult Dose
Oral
Benign prostatic hyperplasia
Adult: 1 (400mcg) capsule once daily. If response is inadequate after 2-4 weeks, may be increased to 800 mcg once daily; if therapy is interrupted, should be resumed at 400 mcg once daily
Hepatic impairment
Mild to moderate: Dosage adjustment not necessary
Severe: Not studied
Child Dose
Renal Dose
Renal impairment
CrCl ?10 mL/min: Dosage adjustment not necessary
CrCl <10 mL/min: Not studied
Administration
Prolonged release tab: May be taken with or without food. Swallow whole, do not chew/crush.
Cap: Should be taken with food. Take ½ hr following the same meal daily. Swallow whole, do not open/chew/crush.
Contra Indications
Hypersensitivity to sulfonamide, severe hepatic impairment, lactation. History of orthostatic hypotension.
Precautions
Hypersensitivity to Tamsulosin Hydrochloride. A history of orthostatic hypotension; severe hepatic insufficiency. As with other alpha1 blockers, a reduction in blood pressure can occur in individual cases during treatment with Tamsulosin, as a result of which, rarely, syncope can occur. At the first signs of orthostatic hypotension (dizziness, weakness) the patient should sit or lie down until the symptoms have disappeared. And they should be cautioned to avoid situations where injury could result (like driving, operating machinery or performing hazardous tasks).
Before therapy with Tamsulosin is initiated the patient should be examined in order to exclude the presence of other conditions which can cause the same symptoms as Benign Prostatic Hyperplasia. Digital rectal examination and when necessary determination of Prostate Specific Antigen (PSA) should be performed before treatment and at regular intervals afterwards. The treatment of severely renal impaired patients (creatinine clearance is less than10ml/min) should be approached with caution as these patients have not been studied. Caution should be exercised in porphyria or allergic reaction to this or any other medicine.
Pregnancy-Lactation
Pregnancy
No data are available on use in pregnant women
No adverse developmental effects observed in animal studies administering tamsulosin to rats or rabbits during organogenesis
Infertility
Males: Abnormal ejaculation including ejaculation failure, ejaculation disorder, retrograde ejaculation, and ejaculation decrease has been associated with therapy; studies in rats revealed significantly reduced fertility in males considered to be due to impairment of ejaculation, which was reversible
Females: Drug is not indicated for use in women; female fertility in rats was significantly reduced, considered to be due to impairment of fertilization
Lactation
There are no data on presence of drug in human milk, effects on breastfed infant, or on milk production
No data are available; owing to potential of tamsulosin to cause hypotension, breastfeeding is not recommended if taking tamsulosin
Interactions
Increased plasma concentration w/ strong CYP3A4 inhibitors (e.g. ketoconazole). Moderate CYP3A4 inhibitors (e.g. erythromycin), strong (e.g. paroxetine) or moderate (e.g. terbinafine) CYP2D6 inhibitors may increase exposure of tamsulosin. Increased plasma concentration w/ cimetidine. Additive effect w/ other ?-adrenergic blocking agents. Concomitant use w/ PDE5 inhibitors may lead to symptomatic hypotension. Decreased plasma concentration w/ furosemide.
Side Effects
Side effects of Tamsulosin Hydrochloride :
>10%
Headache (19-21%), Orthostatic hypotension (6-19%), Rhinitis (13-18%), Abnormal ejaculation (8-18%), Dizziness (15-17%), Arthralgia (11%), Infection (9-11%)
1-10%
Asthenia (8%), Back pain (7-8%), Skin rash (7%), Pharyngitis (5-6%), Diarrhea (4-6%), Myalgia (5%), Chest pain (4%), Cough (3-4%), Somnolence (3-4%), Nausea (2-4%), Sinusitis (2-4%), Abdominal discomfort (2-3%), Bitter taste (2-3%), Decreased libido (1-2%), Insomnia (1-2%)
Mode of Action
Tamsulosin is a selective alpha1 adrenoreceptor-blocking agent. Smooth muscle tone is mediated by the sympathetic nervous stimulation of alpha1 adrenoreceptors, which are abundant in the prostate, prostatic capsule, prostatic urethra, and bladder neck. Blockade of these adrenoceptors can cause smooth muscles in the bladder neck and prostate to relax, resulting in an improvement in urine flow rate and reduction in symptoms in BPH.
Note
Ezipas 400mcg Capsule generic name is Tamsulosin Hydrochloride. Ezipas 400mcg Capsule is manufactured by Leon Pharmaceuticals Ltd.Ezipas is availble in all over Bangladesh.
Mes BD drug index information on Ezipas Capsule is not intended for diagnosis, medical advice or treatment; neither intended to be a substitute for the exercise of professional judgment.