Exemis Film Coated Tablet
Exemestane
25mg
Eskayef Pharmaceuticals Ltd.
| Pack size | 1's pack |
|---|---|
| Unite Price | 100.00 BDT |
Indications
Exemis Film Coated Tablet is used for:
Breast cancer in postmenopausal women
Adult Dose
Oral
Advanced or locally advanced breast cancer
Adult: In women who are no longer responsive to anti-oestrogen therapy: 25 mg once daily.
Child Dose
Renal Dose
Administration
Should be taken with food. Take after a meal.
Contra Indications
Hypersensitivity. Premenopausal women. Pregnancy and lactation.
Precautions
Hepatic and renal impairment. Monitor bone mineral density at regular intervals especially in patients at risk of osteoporosis.
Lactation: Excretion in milk unknown; because of potential for serious adverse reactions in breast-fed infants, advise women not to breastfeed during treatment and for 1 month after final dose
Pregnancy-Lactation
Pregnancy Category: X
Lactation: Excretion in milk unknown; because of potential for serious adverse reactions in breast-fed infants, advise women not to breastfeed during treatment and for 1 month after final dose
Interactions
May result in reduced plasma levels of exemestane when used with CYP3A4 enzyme inducers. Oestrogen-containing drugs; St. John's wort, black cohosh, dong quai.
Side Effects
Side effects of Exemestane :
>10%
Fatigue (22%), Nausea (18%), Hot flashes (13%), Depression (13%), Pain (13%), Insomnia (11%)
1-10%
Anxiety (10%), Dyspnea (10%), Dizziness (8%), Headache (8%), Edema (7%), Vomiting (7%), Flu-like syndrome (6%), Abdominal pain (6%), Anorexia (6%), Cough (6%), Hypertension (5%), Constipation (5%), Diarrhea (4%)
<1%
Cardiac failure, Uterine polyps, Endometrial hyperplasia, Gastric ulcer
Frequency not defined
Hepatitis, Visual disturbances
Mode of Action
Exemestane is an irreversible selective aromatase inhibitor which acts as a false substrate for the aromatase enzyme, forming an intermediate that binds irreversibly to the active site causing its inactivation. It also lowers circulating oestrogens in estrogen-dependent breast carcinoma.
Note
Exemis 25mg Film Coated Tablet generic name is Exemestane. Exemis 25mg Film Coated Tablet is manufactured by Eskayef Pharmaceuticals Ltd.Exemis is availble in all over Bangladesh.
Mes BD drug index information on Exemis Film Coated Tablet is not intended for diagnosis, medical advice or treatment; neither intended to be a substitute for the exercise of professional judgment.