Indications
Erloren Tablet is used for:
Small cell lung cancer, Pancreatic cancer
Adult Dose
Oral
Locally advanced or metastatic non-small cell lung carcinoma
Adult: 150 mg once daily until disease progression or unacceptable toxicity. Reduce dose in decrements of 50 mg when necessary.
Locally advanced, unresectable or metastatic pancreatic cancer
Adult: As 1st-line treatment with gemcitabine: 100 mg once daily, reduce dose in decrements of 50 mg when necessary.
Child Dose
Safety and efficacy not established
Renal Dose
Administration
Should be taken on an empty stomach. Take on an empty stomach at least 1 hr before or 2 hr after meals.
Contra Indications
Hypersensitivity.
Precautions
Pregnancy and lactation. Interrupt Erlotinib therapy if patient develops unexplained pulmonary symptoms e.g. dyspnoea, cough, fever; discontinue therapy if interstitial lung disease is diagnosed. Monitor liver functions periodically; extreme caution is needed if total bilirubin is 3x >ULN; close monitoring is required in patients with hepatic impairment. Interrupt/discontinue therapy if severe changes in liver functions (doubling of total bilirubin and/or tripling of transaminases) occur. Interrupt therapy in the event of dehydration especially in patients with predisposing factors to renal failure.
Monitor renal function and serum electrolytes in patients at risk of dehydration. Interrupt or discontinue therapy if patient develops severe bullous and exfoliative skin disorders; eye pain or other acute/worsening ocular disorders. If patient develops GI perforation, discontinue therapy permanently. Patients with CV disorders. Monitor prothrombin time/INR in patients taking warfarin or other coumarin-derivative anticoagulants.
Lactation: excretion in milk unknown/not recommended
Pregnancy-Lactation
Pregnancy
Based on animal data and its mechanism of action, erlotinib can cause fetal harm when administered to a pregnant woman
Advise females of reproductive potential to use effective contraception during treatment and for 1 month after the last dose
Lactation
No data exist on the presence of erlotinib in human milk, or the effects of erlotinib on the breastfed infant or on milk production
Because of the potential for serious adverse reactions in breastfed infants, including interstitial lung disease, hepatotoxicity, bullous and exfoliative skin disorders, microangiopathic hemolytic anemia, with thrombocytopenia, ocular disorders, and diarrhea
Advise a lactating woman not to breastfeed during treatment and for 2 weeks after the final dose
Interactions
Increased serum levels w/ potent CYP3A4 inhibitors (e.g. ketoconazole, clarithromycin, atazanavir). CYP3A4 inducers (e.g. rifampicin, carbamazepine, phenytoin, phenobarbital) may reduce exposure of erlotinib. Increased serum levels w/ potent inhibitors of CYP1A2 (e.g. ciprofloxacin) or capecitabine. Use w/ P-glycoprotein inhibitors (e.g. ciclosporin, verapamil) may cause altered distribution or elimination of erlotinib. Drugs that increase the pH of the GI tract (e.g. antacids, H2-receptor antagonists, or PPIs) may reduce the solubility of erlotinib thus lowering its bioavailability. Concomitant use w/ warfarin or other coumarin derivates may increase INR and bleeding events.
Side Effects
Side effects of Erlotinib :
>10%
Rash (75-76%), Anorexia (52-69%), Diarrhea (54-55%), Fatigue (52-79%), Nausea (33-40%), Infection (39%), Vomiting (23-25%), Dyspnea (24%), Stomatitis (17-19%), Cough (16%), Pruritus (13%), Conjunctivitis (12%), Dry skin (12%), Keratoconjunctivitis sicca (12%), Abdominal pain (11%)
1-10%
Elevated LFT's (grade 2), Acne, Paronychia, Weight loss, Pneumonitis pulmonary infiltrate, Pulmonary fibrosis
<1%
Interstitial lung disease-like events
Mode of Action
Erlotinib is an epidermal growth factor receptor/human epidermal growth factor receptor type 1 (EGFR/HER1) tyrosine kinase inhibitor. It reversibly inhibits the kinase activity of EGFR, preventing autophosphorylation of tyrosine residues associated w/ the receptor, thereby inhibiting further downstream signaling and resulting in cell death.
Note
Erloren 150mg Tablet generic name is Erlotinib. Erloren 150mg Tablet is manufactured by Renata LimitedErloren is availble in all over Bangladesh.
Mes BD drug index information on Erloren Tablet is not intended for diagnosis, medical advice or treatment; neither intended to be a substitute for the exercise of professional judgment.